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Vol. 19, Art. 17 (pp. 237-248)    |    2018       

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The effect of reversible cholinesterase inhibitor on morphofunctional state of skeletal muscular tissue of rats performing intensive physical work

Vetryakov O.V., Fateev I.V., Fisun A.Y., Vladimirova O.O., Alekseeva I.I., Fedonyk V.P., Egorova N.A.

1 Military Medical Academy. CM. Kirova, St. Petersburg
2 State Scientific Research Institute of Military Medicine, RF Ministry of Defense, St. Petersburg

Brief summary

In experiments on white outbred male rats the effect of reversible cholinesterase inhibitor ipidacrine in 5-day course administration of 1 and 2 mg/kg on morphological and electrophysiological characteristics of skeletal muscle when performing intensive physical work on the background of sleep deprivation was studied. It was shown that a course intraventricular administration of ipidacrine in a dose 1 mg/kg led to minimization of intensity of muscle tissue damage and decrease of a degree of functional disorders in neuromuscular transmission. On the background the administration of ipidacrine in a dose 2 mg/kg led to decrease of intensity of muscle tissue damage and recovery of factors characterizing the effectiveness of neuromuscular transmission up to a level of intact animals, the enhancement of muscular contraction intensity in laboratory animals was also noted. Findings allow to consider ipidacrine as a perspective candidate in a composition of pharmacological correction circuits for physical work capacity in case of a highly intensive physical activity.


Key words

Ipidacrine, physical working capacity, morphofunctional state of skeletal muscle

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