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"Институт токсикологии Федерального медико-биологического агентства"

Институт теоретической и экспериментальной биофизики Российской академии наук.


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199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система

Vol. 18, Art. 1 (pp. 1-49)    |    2017       

Organofluorine compounds for biomedical investigation in vivo with MRI application.
Gervits L.L.

A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academi of Scienses

Brief summary

1H magnetic resonance imaging (MRI) becomes an indispensable tool for determination of the state of disease at the level of description of anatomic changes. At the same time, the identification of specific tissues and the observation of biological processes at the cellular level requires molecular imaging. One of the ways to get such information is provided by 19F MRT. This approach is realizable due to the availability of stable nanosize perfluorocarbon emulsions developed for the use as a blood substitute of oxygen carriers. The capabilities of these emulsions in 19F MRI - in combination with MRT- contrasting substances, various cells, and medical products - are described in this review article. The article provides a general idea of the state of research in the given area and also discusses the outlook for the use and development of some research directions.

Key words

19F Magnetic Resonance Imaging (MRI), Perfluorocarbons, Perfluorocarbon emulsions, Nanoparticles, Contrast agents.

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