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"Институт токсикологии Федерального медико-биологического агентства"
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Институт теоретической и экспериментальной биофизики Российской академии наук.

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199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 16, Art. 75 (pp. 826-833)    |    2015       
»

Cytogenetic abnormalities in rheumatoid arthritis associated with autoimmune thyroiditis
Odin V.I., Dvorovkin A.E., Kolubaeva S.N., Tyrenko V.V., Toporkov M.M., Tzygan E.N.

FGBVOU VPO "Military Medical Academy named after S.M. Kirov" Defense of the Russian
Federation , St. Petersburg, Lebedeva str.,



Brief summary

Autoimmune thyroiditis and rheumatoid arthritis are the most common and often co-occurring autoimmune diseases that share common mechanisms immunopathogenesis. The pilot studies were examined 8 patients who were analyzed by cytogenetic abnormalities. Only patients with autoimmune thyroiditis noted a significant increase in the number of cytogenetic abnormalities after irradiation, including increasing the number of clones in the 6-fold compared to the spontaneous level (p <0,05). But in patients with rheumatoid arthritis associated with autoimmune thyroiditis it was revealed a significant increase in baseline common cytogenetic damage in comparison with group of patients only autoimmune thyroiditis (100,8 vs. 61,4, respectively (p <0,05). Thus, the formation of genetic instability in patients with rheumatoid arthritis are associated with autoimmune thyroiditis occurs more deeply that seems to be associated with the syndrome of mutual aggravation. To clarify the nature of these relationships further research is needed.


Key words

rheumatoid arthritis, autoimmune thyroiditis, cytogenetic abnormalities





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