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Vol. 16, Art. 65 (pp. 717-722)    |    2015       

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The frequency of hyperhomocysteinemia and its possible influence on clinical features in patients with hemophilia summary

FSBI «Russian scientific research institute of hematology and transfusiologyof Federal medical biologic agency», Saint Petersburg, Russia, e-mail: RNIIHT@mail.ru

Brief summary

Preliminary data on the presence of hyperhomocysteinemia, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in the group of patients with severe hemophilia are presented. The association between hyperhomocysteinemia, presence of hepatitis C virus and several clinical features has been studied.


Key words

hemophilia, chronic synovitis, arthritis, homocysteine, methylenetetrahydrofolate reductase, gene, polymorphism, hepatitis C virus.

Reference list

1. Van der Berg H.M, Dunn A, Fischer K, Blanchette V.S. Prevention and treatment of musculoskeletal disease in the haemophilia population: role of prophylaxis and synovectomy // Haemophilia. – 2006.- N 12, Suppl. 3. – P. 159–168.


2. Donna M. DiMichele. Treatment of Hemophilia// Monograph Series, No. 7 Published in 1997, revised 2000.


3. Roosendaal G, Vianen ME, Wenting MJG et al. Iron deposits and catabolic properties of synovial tissue from patients with haemophilia// J Bone Joint Surg Br. – 1998. – Vol. 80. – P. 540–545.


4. Jakubowski H, Homocysteine-thiolactone and protein N-homocysteinylanion in human// Abstracts of 3rd conference on hyperhomocysteinemia. Saarbrucken, 2003. – P.7-8.


5. Shmeleva V.M. Rol gipergomocisteinemii v formirovanii protromboticheskih naryshenii sistemi gemostaza. // Avtoref. diss. … d-ra. med. nayk, 2010. – 23 s.


6. Shmeleva V.M., Ribakova L.P. Sostoyanie okislitelnoi i antiokislitelnoi sistem y bolnih s aterosklerozom pri nalichii i v otsytstvii gipergomocisteinemii // Kazanskii medicinskii jyrnal. – 2008. – T.89, №3. – S.281-285.


7. Byrakov V.V., Kargin V.D., Soldatenkov V.E. Kompleksnoe lechenie gemofilicheskoi artropatii s ispolzovaniem vnytrisystavnogo vvedeniya lekarstvennih sredstv pod yltrazvykovim kontrolem // Vestnik gematologii. – 2009. – T. V, № 2. – S. 66-67