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 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 13, Art. 70 (pp. 841-852)    |    2012       
»

Platelets dysfunction as the cause of hemorrhagic diathesis in women
Saparkina M.V. 1, Koloskov A.V. 1,2, Philippova O.I. 2, Stolitsa A.A. 1

1Almazov federal heart, blood and endocrinology centre
2City Hospital № 26, St.Petersburg, Russia



Brief summary

The concept of "hemorrhagic diathesis" unites a group of different diseases and syndromes, the hallmark of which is pathological bleeding (spontaneous and provoked), which may be due to different pathogenetic mechanisms. For women, this disease is a more pressing problem than for men, due to their physiological characteristics (availability of monthly menstrual blood loss and the function of reproduction, which may be associated with profuse blood loss). The most common manifestation of bleeding disorders in women are menorrhagia, as women with bleeding disorders susceptible to chronic anemia with iron deficiency, more active bleeding with endometriosis, bleeding in benign conditions such as fibroids, endometrial hyperplasia and polyps, and hemorrhagic ovarian cysts. Also available are a variety of obstetric complications, including spontaneous abortion, obstetric hemorrhage, especially postpartum. Most bleeding manifestations are not unique to women with bleeding disorders, they are just more serious and more evident. In this review highlight a fairly common condition that leads to the symptoms of abnormal bleeding in women - thrombocytopathies.


Key words

hemorrhagic diathesis, thrombocytopathies, platelets dysfunction, menorrhagia





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Reference list

1. James AH. Bleeding disorders in adolescents / AH. James // Obstet Gynecol Clin North Am., 2009. – Vol.36, № 1. – P. 153-162.


2. Hallberg L. Menstrual blood loss – a population study. Variation at different ages and attempts to define normality/ L Hallberg, AM. Hogdahl, L. Nilsson, G. Rybo // Acta Obstet Gynecol Scand., 1966. – Vol. 45, № 3 . – P. 320–351.


3. Janssen CAH. Reconsidering menorrhagia in gynecological practice. is a 30-year-old definition still valid? / CAH. Janssen, PC. Scholten , APM. Heintz // Eur J Obstet Gynecol Reprod Biol ., 1998. - Vol. 78, № 4. – P. 69-72.


4. Higham JM. Assessment of menstrual blood loss using a pictorial chart / JM. Higham, PM. O’Brien, RW.Shaw // Br J Obstet Gynaecol., 1990. – Vol. 97. – P. 734–739.


5. Reid PC. Assessment of menstrual blood loss using a pictorial chart: a validation study / PC. Reid, A. Coker, R. Coltart // Br J Obstet Gynaecol., 2000 . – Vol. 107. – P. 320–322.


6. Wyatt KM . Determination of total menstrual blood loss / KM. Wyatt , PW. Dimmock , TJ Walker , PM. O'Brien // Fertil Steril., 2001. – Vol.76, № 1. - P. 31-125.


7. Mannucci PM. Recessively inherited coagulation disorders / PM.Mannucci , S. Duga, F.Peyvandi // Blood, 2004. – Vol. 104. – P. 1243–1252.


8. Cattaneo M. Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate / M. Cattaneo // Thromb Haemost., 2011. – Vol. 105, № 1. – P.67–74.


9. Kirtava A. Medical, reproductive and psychosocial experiences of women diagnosed with von Willebrand's disease receiving care in haemophilia treatment centres: a case-control study / A.Kirtava , C. Drews, C. Lally, et al. // Haemophilia, 2003. - Vol. 9,№3. – P. 292– 297.


10. Biss TT. Use of a quantitative pediatric bleeding questionnaire to assess mucocutaneous bleeding symptoms in children with a platelet function disorder / TT. Biss, VS. Blanchette, DS. Clark, et al. // J Thromb Haemost, 2010. – Vol. 8. – P.1416–1419.


11. Quiroga T. High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls / T. Quiroga, M. Goycoolea, O. Panes, et al. // Haematologica, 2007. – Vol. 92. – P. 357–365.


12. Nair S. Glanzmann’s thrombasthenia: updated / S.Nair, K. Ghosh, B. Kulkarni, et al. // Platelets, 2002. – Vol. 13. – P. 387–393.


13. Leticee N. Pregnancy in mother with Glanzmann’s thrombasthenia and isoantibody against GPIIb-IIIa: Is there a foetal risk? / N. Leticee, C. Kaplan, D. Lemery // Eur J Obstet Gynecol Reprod Biol., 2005. – Vol. 121. – P.139–142.


14. Lopez JA. Bernard-Soulier syndrome / JA. Lopez, RK. Andrews, V. Afshar-Kharghan, MC. Berndt // Blood, 1998. – Vol. 91. – P. 4397–4418.


15.Ware J. Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome / J. Ware, SR. Russell, P. Marchese, et al. // J Clin Invest., 1993. – Vol. 92. – P. 1213–1220.


16. Miller JL. Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease / JL. Miller, VA. Lyle, D.Cunningham // Blood, 1992. – Vol.79. – P. 439–446.


17. Miller JL. Platelet-type von Willebrand’s disease: characterization of a new bleeding disorder / JL. Miller, A. Castella // Blood, 1982. – Vol. 60. – P. 790–794.


18. Moriki T. Expression and functional characterization of an abnormal platelet membrane glycoprotein Ib alpha (Met239 —> Val) reported in patients with platelet-type von Willebrand disease / T. Moriki, M. Murata, T. Kitaguchi, et al. // Blood, 1997. – Vol .90. – P. 698–705.


19. Takahashi H. Further characterization of platelet-type von Willebrand’s disease in Japan / H.Takahashi , M. Handa, K.Watanabe, et al.// Blood, 1984. – Vol. 64. – P. 1254–1262.


20. Takahashi H. Substitution of Val for Met at residue 239 of platelet glycoprotein Ib alpha in Japanese patients with platelet-type von Willebrand disease / H.Takahashi, M. Murata, T. Moriki, et al.// Blood, 1995. – Vol. 85. – P. 727–733.


21. Miller JL. Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disase / J.L.Miller, D. Cunningham, VA. Lyle, CN. Finch // Proc Natl Acad Sci U S A, 1991. – Vol. 88. – P. 4761–4765.


22. Gachet C. Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors / C. Gachet, M .Cattaneo, P. Ohlmann, et al.// Br J Haematol., 1995. – Vol.91. – P.434–444.


23. Hollopeter G. Identification of the platelet ADP receptor targeted by antithrombotic drugs / G. Hollopeter, HM. Jantzen, D. Vincent, et al. // Nature., 2001. – Vol. 409 . - P. 202–207.


24. Nurden P. An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function / P.Nurden, P. Savi, E. Heilmann, et al. // J Clin Invest.,1995. – Vol.95. – P.1612–1622.


25. Nieuwenhuis HK. Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading / HK. Nieuwenhuis,KS. Sakariassen, WP. Houdijk, et al. // Blood, 1986. – Vol. 68. – P.692– 695.


26. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion / M. Moroi, S.M. Jung, M. Okuma, et al. // J Clin Invest.,1989. – Vol. 84. – P. 1440–1445.


27. Nurden P. Severe deficiency of glycoprotein VI in a patient with gray platelet syndrome / P.Nurden, M. Jandrot-Perrus, R .Combrie, et al. // Blood, 2004. – Vol.104. – P. 107–114.


28. Holmsen H. Secretable storage pools in platelets / H. Holmsen, HJ.Weiss // Annu Rev Med., 1979. – Vol.30. – P.119–134.


29. Holmsen H. Further evidence for a deficient storage pool of adenine nucleotides in platelets from some patients with thrombocytopathia—”storage pool disease” / H. Nolmsen, H.J. Weiss // Blood, 1972. – Vol.39. – P. 197–209.


30. Rao AK. Inherited defects in platelet signaling mechanisms / A.K. Rao // J Thromb Haemost., 2003 – Vol.1. – P. 671–681.


31. Zwaal RF. Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids / RF. Zwaal, P. Comfurius, EM.Bevers // Biochim Biophys Acta., 2004. – Vol. 1636. – P. 119–128.


32. Myles PS. Stopping aspirin before coronary artery surgery between the devil and the deep blue sea / PS. Myles // Circulation, 2011. – Vol. 123. – P.571–573.


33. Cattaneo M. The platelet P2Y12 receptor for adenosine diphosphate: congenital and druginduced defects / M .Cattaneo // Blood, 2011 . – Vol.117. – P. 2102–2112.


34.Wiviott SD. Prasugrel versus clopidogrel in patients with acute coronary syndromes / SD. Wiviott , E. Braunwald , CH. McCabe , et al.// N Engl J Med., 2007. – Vol.357. – P.2001– 2015.


35. Mukamal KJ. Alcohol consumption and platelet activation and aggregation among women and men: the Framingham offspring study / K.J. Mukamal, J.M. Massaro, K.A. Ault et al.// Alcohol Clin Exp Res., 2005. – Vol. 29. – P. 1906–1912.


36. Hedges SJ. Evidence-based treatment recommendations for uremic bleeding / S.J. Hedges, S.B. Dehoney, J.S. Hooper et al. // Nat Clin Pract Nephrol., 2007. – Vol.3. – P. 138–153.


37. Papadakis E.Thrombohemorrhagic complications of myeloproliferative disorders / E.Papadakis, R. Hoffman, B. Brenner // Blood Rev., 2010 . – Vol.24. – P. 227–232.


38. Pamphilon D.H. The myelodysplastic syndromes–a study of haemostatic function and platelet ultrastructure / D.H. Pamphilon, S.R. Aparicio, B.E. Roberts et al.// Scand J Haematol.,1984. – Vol. 33. – P. 486–491.


39. Zangari M. Hemostatic dysfunction in paraproteinemias and amyloidosis / M.Zangari, F. Elice, L. Fink, at al. // Semin Thromb Hemost., 2007. – Vol. 33. – P. 339–349.



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