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 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 13, Art. 56 (pp. 672-681)    |    2012       
»

Identification of Mycobacterium tuberculosis genotypes, associated with the drug resistance and the drug susceptibility
Dymova M.A., Alkhovik O.I., Cherednichenko A.G., Kozhamkulov U.A., Petrenko T.I., Ramankulov E.M., Filipenko M.L.



Brief summary

A molecular genetic study was performed using VNTR-typing of 1454 Mycobacterium tuberculosis isolates which circulating in different areas (Russia, Kyrgyzstan, Kazakhstan, Peru) in order to identify the association between belonging to a specific genetic family and the presence or absence of multidrug resistance (MDR). It was found an association between the presence of MDR and belonging to the type M2 (χ2 = 0.167, p = 0.000), type M11 (χ2 = 0.145, p = 0.000), a group of MST types № 548 (χ2 = 0.090, p = 0.003) of Beijing family M. tuberculosis. MST type № 540 was associated with the absence of MDR (χ2 = 0.081, p = 0.008). Similar results were obtained for the Haarlem family (χ2 = 0.138, p = 0.000), T65 group (χ2 = 0.096, p = 0.001), for the URAL family (χ2 = 0.102, p = 0.001), and for group T16 (χ2 = 0.114, p = 0.000). These data contribute to a better understanding of the molecular epidemiology of tuberculosis, and the adoption of effective preventive measures against the disease.


Key words

Mycobacterium tuberculosis, drug resistance, molecular epidemiology





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