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Vol. 12, Art. 54 (pp. 646-664)    |    2011       

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Management of patient with paralel current of multiple myeloma and primary myelofibrosis

S.S. Bessmeltsev, N.A. Romanenko, K.M. Abdulkadyrov, N.A. Potikhonova, M.N. Zenina, V.I. Rugal

Russian Research Institute of Hematology and Transfusiology, Russian Federal Medicobiological Agency, St.-Petersburg

Brief summary

In the article is presented the case report of a patient with simultaneously developed lymphoid and myeloid neoplasms. Diagnosis’s of multiple myeloma and primary myelofibrosis were confirmed by complete blood count, myelogramm, trephinebiopsy, immunohistochemical, cytogenetic, biochemical and x-ray’s examination. Complete remission of multiple myeloma was achieved after 7 cycles «VAD» and treatment with Recombinant Erythropoietin Beta during 11 weeks with subsequent maintenance therapy cycles of Bortezomib and Interferon Alpha. However, primary myelofibrosis was progressed to blastic crisis. Disease’s progression was delayed with 3 therapy cycles «5+2». But 3 months later hemorrhagic syndrome appeared and patient died.


Key words

multiple myeloma, primary myelofibrosis, erythropoietin, plasmatic cells, acute myeloid leukemia, anemia, bone destruction

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