Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 16, Art. 12 (pp. 138-149)    |    2015       

»

Basic evaluation methods of neurotoxic effects of severe forms of acute ethanol intoxication

Lisitskiy D.S., Voytsekhovich K.O., Melehova A.S.

Federal State Institution of Science "Institute of Toxicology, Federal Medical-Biological Agency"

Brief summary

Comprehensive definition of indicators defining the state of behavioral, sensorial, neuromotor and cognitive functions in experimental animals gives insight into pathological processes caused by neurotoxicants, including ethanol. Experimental study of neurotoxic disorders and dynamics of the disturbed functions recovery allows evaluating of their severity and duration, and can also be used in efficiency determination and explanation of application of pharmacological preparations in rehabilitation of patients who underwent severe acute alcohol intoxication.


Key words

Open field, X-maze, conditioned instrumental active and passive escape response, Rota road test, Tail flick, ethanol.

Reference list

1. Grebenuk, A.N. Eksperimentalnaya ocenka neirotoksicheskih effektov etanola i ih korrekciya peptidnimi preparatami / A.N. Grebenuk, V.L. Reinuk, D.A. Halutin, E.V. Davidova // Mediko-biologicheskie i socialno-psihologicheskie problemi bezopasnosti v chrezvichainih sityaciyah. – 2014. – № 3. – S. 70-77.


2. Tilson, H.A. Neurobehavioral techniques to assess the effects of chemicals on the nervous system / H.A. Tilson, C.L. Mitchell // Ann Rev Pharmacol Toxicol. – 1984. – № 24. – P. 425-450.


3. Sofronov, G.A., Shilov, V.V. Eksperimentalnaya toksikologiya / Pod red. G.A. Sofronova i V.V. Shilova. – SPb.: «ELBI-SPb», 2011. – 272 s.


4. Hamm, R.J. The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury / R.J. Hamm, B.R. Pike, D.M. O’Dell et al. // J. Neurotrauma. – 1994. – № 11. – P. 187-196.


5. Moser, V.C. Observational batteries in neurotoxicity testing / V.C. Moser // Int. J. Toxicol. – 2000. – № 19. – P. 407-411.


6. Vorhees, C.V. Methods for detecting long-term CNS dysfunction after prenatal exposure to neurotoxins / C.V. Vorhees // Drug Chem. Toxicol. – 1997. – № 20. – P. 387-399.


7. Calton, J.L. Where am I and how will I get there from here? A role for posterior parietal cortex in the integration of spatial information and route planning / J.L. Calton, J.S. Taube // Neurobiol Learn Mem. – 2009. – № 91. – P. 186-196.


8. Ehman, K.D. Evaluation of cognitive function in weanling rats: a review of methods suitable for chemical screening / K.D. Ehman, V.C. Moser // Neurotoxicol Teratol. – 2006. – № 28. – P. 144-161.


9. Lisickii, D.S. Farmakologicheskaya korrekciya posledstvii neirotoksicheskih porajenii pri tyajyolih formah ostrih otravlenii etanolom : avtoref. dis. ... kand. biol. nayk : 14.03.04, 14.03.06 / Lisickii Dmitrii Sergeevich. – Sankt-Peterbyrg, 2013. – 26 s.


10. Shevchyk, M.K. Ispolzovanie metodiki krestoobraznogo labirinta dlya toksikologicheskoi ocenki bezopasnosti slaboalkogolnih napitkov / M.K. Shevchyk, A.N. Petrov, E.K. Georgianova, A.V. Lichakov // Toksikologicheskii vestnik. – 2005. – № 3. – S. 25.


11. Dolgo-Sabyrov, V.B. Centralnie neirohimicheskie effekti ostrogo i hronicheskogo vozdeistviya etanola. Mehanizmi tolerantnosti i zavisimosti (obzor literatyri) / V.B. Dolgo-Sabyrov, A.N. Petrov, D.S. Lisickii, V.A. Belyaev // Biomedicinskii jyrnal Medline.ru. – 2011. – Tom 12. – S. 1423-1436.


12. Osechkina, N.S. Vliyanie ekspressii i polimorfizma genov, kodiryushih GAMK-receptori, na tyajest deprimiryushego deistviya etanola y kris / N.S. Osechkina, G.V. Nazarov, E.U. Bonitenko, M.B. Ivanov, V.A. Kashyro, N.V. Lapina, A.V. Babkin, I.S. Berdinskih, A.S. Melehova, K.O. Voicehovich, D.S. Lisickii, N.V. Makarova, T.V. Kashina // Toksikologicheskii vestnik. – 2014. – № 6. – S. 22-27.


13. Lisickii, D.S. Primenenie avtomatizirovannih sistem Laboras i Open field dlya ocenki povedeniya i dvigatelnoi aktivnosti jivotnih posle ostrogo alkogolnogo otravleniya / D.S. Lisickii, A.S. Melehova // Sbornik materialov I Vserossiiskoi naychno-prakticheskoi konferencii s mejdynarodnim ychastiem «Innovacii v zdorove nacii», SPHFA, Sankt-Peterbyrg, 20 noyabrya 2013 g. – SPb.: Izd-vo SPHFA, 2013. – S. 49-50.


14. Bertelli, J.A. The rat brachial plexus and its terminal branches: an experimental model for the study of peripheral nerve regeneration / J.A. Bertelli, M. Taleb, A. Saadi et al. // Microsurgery. – 1995. – № 16(2). – P. 77-85.


15. Voronina, T.A. Metodicheskie ykazaniya po izycheniu trankviliziryushego (anksioliticheskogo) deistviya farmakologicheskih veshestv / T.A. Voronina, S.B. Seredenin // Rykovodstvo po eksperimentalnomy (doklinicheskomy) izycheniu novih farmakologicheskih veshestv. – M., 2000. – S. 126-130.


16. Zaharov, V.V. Kognitivnie rasstroistva v pojilom i starcheskom vozraste: Metodicheskoe posobie dlya vrachei / V.V. Zaharov, N.N. Yahno. – M., 2005. – 71 s.


17. Byresh, Ya. Metodiki i osnovnie eksperimenti po izycheniu mozga i povedeniya / Ya. Byresh, O. Byreshova, D.P. Huston. – M.: Visshaya shkola, 1991. – 399 s.


18. Kryglikov, R.I. Neirohimicheskie mehanizmi obycheniya i pamyati / R.I. Kryglikov. – M.: «Nayka», 1981. – 211 s.


19. Lisickii, D.S. Farmakologicheskaya korrekciya naryshenii kognitivnih fynkcii y kris posle tyajyoloi formi ostrogo otravleniya etanolom na fone predvaritelnoi alkogolizacii / D.S. Lisickii, A.S. Melehova // Sbornik trydov IV Sezda toksikologov Rossii s mejdynarodnim ychastiem, Moskva, 6-8 noyabrya 2013 g. – M.: Izdatelstvo Capital Press, 2013. – S. 289-291.


20. Lisickii, D.S. Primenenie pikamilona i noopepta, a takje ih sochetaniya y belih kris dlya ystraneniya posledstvii tyajyoloi stepeni ostroi alkogolnoi intoksikacii / D.S. Lisickii, A.N. Petrov, M.K. Shevchyk // Jyrnal «Vestnik Rossiiskoi voenno-medicinskoi akademii». – 2014. – № 1(45). – S. 156-159.


21. Zorina, Z.A. Zoopsihologiya. Elementarnoe mishlenie jivotnih / Z.A. Zorina, I.I. Poletaeva. – M.: «Aspekt Press», 2001. – 320 s.


22. Lisickii, D.S. Farmakologicheskaya korrekciya neirotoksicheskih porajenii y belih kris posle tyajyoloi formi ostroi alkogolnoi intoksikacii / D.S. Lisickii, A.N. Petrov, M.K. Shevchyk // Toksikologicheskii vestnik. – 2013. – № 1. – S. 19-23.


23. Shabanov, P.D. Biologiya alkogolizma / P.D. Shabanov, S.U. Kalishevich. – SPb.: Izd. «Lan», 1998. – 272 s.

Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций

(c) Перепечатка материалов сайта Medline.Ru возможна только с письменного разрешения редакции