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Vol. 24, Art. 62 (pp. 840-859)    |    2023       

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Systemic inflammatory reaction syndrome in the pathogenesis of infectious complications in acute poisoning with substances of neurotropic action

Schilov V.V.1,2, Lukin1 V.A.2

1North-Western State Medical University named after I.I. Mechnikov,
191015, Saint-Petersburg, Russia;
1Saint-Petersburg I.I. Dzanelidze research institute of emergency medicine
192242, Saint-Petersburg, Russia;

Brief summary

413 patients with acute poisoning with neuroleptics and substances of narcotic action of severe degree aged from 19 to 57 years were examined. The aim of the study was to determine the significance of the systemic inflammatory reaction syndrome in the pathogenesis of acute poisoning with severe neurotropic substances. It has been shown that against the background of hypoxia in patients with acute poisoning with neurotropic agents (neuroleptics and narcotic substances) a severe systemic inflammatory reaction syndrome of varying severity is formed, which underlies the formation of infectious complications (pneumonia, sepsis) in the somatogenic phase of intoxication, which are one of the main reasons for increasing the duration of treatment and deaths in this category of patients. Based on the concept of systemic inflammation, a system of early diagnosis and prognosis was developed the formation of infectious complications and deaths, the predictors of the development of which were an increase in serum levels of interleukin-6, interleukin-10, procalcitonin, D-dimer.


Key words

systemic inflammatory reaction; acute poisoning; neuroleptics; drugs; interleukines

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