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Vol. 24, Art. 32 (pp. 431-439)    |    2023       

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Study of acute toxicity of trimethylsilane by inhalation

Oskina D. G., Yerunova N.V.

Federal State Unitary Enterprise "Scientific Research
Institute of Hygiene, Occupational Pathology and Human Ecology" of the Federal Medical and Biological Agency, St. Petersburg

Brief summary

A toxicological and sanitary-chemical study was conducted to experimentally substantiate the approximate safe level of exposure to trimethylsilane in the air of the working area. Experimental studies were performed on males of nonlinear white mice and rats. The parameters of trimethylsilane toxicometry were determined by the inhalation route of entry into the body, as well as by contact with the skin and visible mucous membranes. According to the parameters of acute toxicity, trimethylsilane belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76). The substance has no irritating effect on the skin of experimental animals and the mucous membranes of the eyes. The threshold of a single inhalation action of trimethylsilane to change behavioral reactions and biochemical parameters of blood has been established. In subacute experiments, a weak cumulative effect was revealed, no deaths of experimental rats were recorded during the experiment, functional disorders of breathing and cardiac activity were revealed. The recommended value of the approximate safe level of exposure to trimethylsilane in the air of the working area has been established based on the analysis of literature sources, experimental data obtained and mathematical forecasting.


Key words

approximately safe level; trimethylsilane; working area air; inhalation exposure; acute experiment

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