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Vol. 24, Art. 22 (pp. 305-324)    |    2023       

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Toxicokinetic approaches to the development of effective and safe cyanide antidotes. experimental and theoretical aspects

Gladkikh V.D.

Federal State Unitary Enterprise Scientific and Production Center «Pharmzaschita» Federal Medical and Biological Agency

Brief summary

Based on the analysis of literature data, the article characterizes multiple biotransformation pathways of endogenous cyanide, discusses toxicokinetic approaches to the development of cyanide antidotes. Attention is focused on the shortcomings of modern antidotes and promising directions for improving antidote prevention and treatment of acute cyanide poisoning are considered. The role of potential cyanide antidotes, effective and safe for intramuscular, inhalation and oral delivery, is claimed primarily by chemical compounds mediating anti-cyanide activity by stimulating the main mechanisms of detoxification of endogenous cyanide: sulfangene, cobinamide, ketoglutaric acid derivatives.


Key words

tidotes; detoxification; cobinamide; poisoning; toxicokinetics; sulfangene; cyanides; α-ketoglutaric acid

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