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Vol. 23, Art. 30 (pp. 515-555)    |    2022       

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Perfluorocarbon fluids in the treatment of respiratory distress syndrome (literature review)

Barinov V.A.1,5, Bonitenko E.U.2,3, Belyakova N.A.1, Rodchenkova P.V.2, Tonshin A.A.2, Panfilov A.V.4, Bala A.M.4, Golovko A.I.1, Shilov V.V.5

1FGBI «Scientific and Clinical Center of Toxicology named after S.N. Golikov of the Federal Medical and Biological Agency»
2FGBNU "Scientific Research Institute of Occupational Medicine named after N.F. Izmerov"
3FGAOU GU «Sevastopol State University»
4Foundation for Advanced Study
5FU GU "North-Western State Medical University named after I.I. Mechnikov" of the Ministry of Health of the Russian Federation

Brief summary

Despite the improvement of pharmacological and non-drug methods of treating acute respiratory distress syndrome, mortality in this pathology remains quite high. The actual direction of treatment of acute respiratory distress syndrome is the development and introduction into clinical practice of various options of liquid ventilation of the lungs using perfluorocarbon organic compounds. The advantages of this direction, largely due to the unique physicochemical and gas transport properties of perfluorocarbon liquids, include improving of oxygen delivery, increasing the elasticity of the lungs, eliminating conditions for the formation of atelectasis, as well as anti-inflammatory action. The review presents the main data on the results of the use of perfluorocarbon fluids as agents for the treatment of acute respiratory distress syndrome through the introduction of different variants of medical technology of liquid ventilation of the lungs, published in foreign and domestic literature over the past 50 years. Promising directions of experimental research on substantiation of the use of perfluorocarbon fluids as a means for the treatment of acute respiratory distress syndrome and the development of new medical technologies for the treatment of severe bronchopulmonary pathology using liquid ventilation of the lungs have been determined.


Key words

perfluorocarbon fluids, acute respiratory distress syndrome, partial liquid ventilation of the lungs, full liquid ventilation of the lungs, experimental therapy, treatment of adult patients, treatment of pediatric patients.

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