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Vol. 22, Art. 51 (pp. 718-727)    |    2021       

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Morphogenesis of granulomas with a single intratracheal admissoin of aluminum nanoparticles

Federal State Unitary Enterprise
"Research Institute of Hygiene, Toxicology and Occupational Pathology"
at Federal Medical and Biology Agency

Brief summary

The aim of this work is to study the initial changes in the histoarchitectonics of the lung tissue after a single intratracheal injection of aluminum nanoparticles (NPA). NPA was used as a suspension prepared ex tempore in a 2% alcohol solution in deionized water (in a ratio of 1:24) in a volume of 1.0 ml. Individual weighed portions of 50 mg NPA were injected into laboratory animals intratracheally. The animals were taken out of the experiment after 1, 3, 7, 14 and 28 days to study the primary reaction of the lung tissue in response to NPA exposure, as well as to assess fibrotic processes. The results of the study of the microscopic structure of the lung tissue showed that laboratory animals developed to interstitial-granulomatous pneumoconiosis, which by the nature of the course can be attributed to the rapidly progressive, because the formation of epithelioid granulomas was noted on the 7th day after the introduction of NPA into the lower respiratory tract, but after for 28 days, signs of fibrous degeneration of the lung tissue were detected.


Key words

pneumoconiosis, aluminosis, granulomas, aluminum nanoparticles, extracellular matrix, pulmonary fibrosis

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