Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 22, Art. 45 (pp. 643-649)    |    2021       

»

Efficiency of radioprotectors with different mechanisms of implementation of anti-radiation effect in combined radiation-chemical injury

A.М. Ivanchenko, M.A. Karamullin., A.V. Zavirsky, V.V. Zatsepin, V.A. Basharin, P.G. Tolkach, Y.V. Shilov., Yazenok A.V.

S.M.Kirov Military Medical Academy

Brief summary

In the article is presented the results of an experimental study of radioprotectors with various mechanisms of anti-radiation action in combined radiation-chemical ingury caused by the sequential action of X-rays and carbon monoxide. It is shown that drugs, the protective effect of which is realized by the formation of hypoxia in radiosensitive tissues, do not have a protective effect with this type of combined injury. Prophylactic administration of B-190 and naphazoline led to a significant decrease in the survival rate of laboratory animals and a more pronounced inhibition of hematopoiesis according to the endogenous colony formation test. Prophylactic administration of cystamine, as a drug that provides an antiradiation effect through inactivation of free radicals and direct protection of DNA, showed a distinct protective effect in combined radiation-chemical damage, expressed in an increase in the proportion of surviving animals, a lesser degree of suppression and an earlier onset of hematopoiesis recovery in white mice.


Key words

ionizing radiation, irradiation, intoxication, carbon monooxid, combined radiation injury, radioprotector

Reference list

1. Romanovich I. K., Barkovskii A. N., Stepanov V. S. Obespechenie sanitarno-epidemiologicheskogo blagopolychiya naseleniya Rossiiskoi Federacii pri vozniknovenii radiacionnih avarii i incidentov // Aktyalnie voprosi organizacii kontrolya i nadzora za fizicheskimi faktorami. M. - 2017. - S. 347-350.


2. Kombinirovannie radiacionnie porajeniya - patogenez, klinika, lechenie / Pod red. A.F. Ciba, M.N. Farshatova. ‒ M.: Medicina, 1992. ‒ 320 s.


3. Gladkih V. D., Belih V.G., Timoshevskii A.A., Chij I.M. Specialnie sredstva medicinskoi protivohimicheskoi i protivoradiacionnoi zashiti: sovremennoe sostoyanie i perspektivi razvitiya // Voenno-medicinskii jyrnal. - 2018. - T. 339. - 1. - S. 29-36.


4. Legeza V.I, Grebenuk A.N., Boyarincev V.V. Kombinirovannie radiacionnie porajeniya i ih komponenti. SPb: OOO «Izdatelstvo Foliant», 2015. - 216 s.


5. DiCarlo A.L., Maher C., J.L. Hick, D. Hanfling Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation // Disaster medicine and public health preparedness. - 2011. - Vol. 5, S1. - P. S32-S44.


6. Grehova A.K., Pystovalova M.V., Eremin P.S. Ocenka vklada gomologicheskoi rekombinacii v reparaciu dvynitevih razrivov DNK v fibroblastah cheloveka posle vozdeistviya rentgenovskogo izlycheniya v maloi i srednih // Radiacionnaya biologiya. Radioekologiya. - 2018. - T. 58. - 6. - S. 589-596.


7. Deev R.V., Bilyalov A.I., Jampeisov T.M. Sovremennie predstavleniya o kletochnoi gibeli // Geni i kletki. - 2018. - T. 13. - 1.- S. 6-19.


8. Vasin M.V. Protivolychevie lekarstvennie sredstva // M.: GIYV MO RF. - 2010. - 180 s.