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Vol. 22, Art. 32 (pp. 475-486)    |    2021       

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1-(3-indolyl)-β-carbolines- the new group of perspective antioxidants

1 Federal State Budgetary Institution "Scientific and Clinical Center of Toxicology named after Academician S.N. Golikov Federal Medical and Biological Agency"
2 St. Petersburg State Technological Institute (Technical University)

Brief summary

New pharmacologically promising 1-indole-3-yl derivatives of β-carboline have been obtained. According to the theoretical prediction made using the PASS Online software, the obtained substances are active antioxidants, which was confirmed by in vitro experiments. The data of virtual screening of these substances also allow us to expect psychotropic and antitumor activity.


Key words

β-carboline, Pictet-Spengler reaction, synthesis, antioxidants, PASS Online

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