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"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




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«
Vol. 21, Art. 69 (pp. 854-869)    |    2020       
»

Perftooran. Unused potential of medicine against covid-19.
Institute for Theoretical and Experimental Biophysics, Russian Academy of Sciences
IPI ?Institute of Engineering Physics?, Serpukhov, Moscow Region. Russia



Brief summary

This brief review compares the known clinical symptoms and identified pathogenetic mechanisms of COVID-19 with the unique properties of the Russian gas-carrying blood substitute Perftoran, which is a nanoemulsion of completely fluorinated organic compounds. A generalized analysis of the results of more than 20 years of clinical Perftoran use allows us to propose it as a target agent capable of significantly reducing the harmful effects of key factors responsible for the damage to the human body and deaths in coronavirus infection. Attention is focused on the main features of Perftoran action: the ability to weaken the effect of hemic, circulatory, thromboembolic and respiratory hypoxia, to provide partial replacement of the oxygen-carrying function of damaged erythrocytes and hemoglobin, to exhibit a cytoprotective effect at the level of the lung alveoli, erythrocytes, vascular endothelium and other tissues, to reduce the primary damage and secondary inflammatory alteration. Clinical experience in relief of acute respiratory distress syndrome (ARDS), prevention of disseminated intravascular coagulation, and treatment of thromoembolism with Perftoran is mentioned. Many therapeutic effects have been demonstrated previously with intravenous, as well as with local and aerosol administration of the drug. In fact, the article substantiates the need to restore the industrial manufacturing of Perftoran, which was stopped due to financial reasons.


Key words

COVID-19, Perftoran, antihypoxic, anti-inflammatory, anticoagulant properties, ARDS treatment, thromboembolism, cytoprotection, improving blood flow.





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