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Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




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199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

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«
Vol. 21, Art. 68 (pp. 839-853)    |    2020       
»

Analysis of the effectiveness of the drug based on succinic acid salts for the treatment of osteoporosis
Almazov NMRC of the Ministry of health of the Russian Federation
Institute of theoretical and experimental biophysics
Institute of experimental medicine



Brief summary

We performed an experimental analysis of the pharmacological effectiveness of the drug, created on the basis of a complex of acid salts of calcium and magnesium of the natural succinic acid conformer, in comparison with the well-known anti-osteoporotic drug. Testing was carried out on a model of osteoporosis in female rats that were given prednisolone twice after bilateral ovariectomy. The increment in weight indicators, the increase in the level of calcium and collagen in the tissue of the femur revealed the higher efficiency of the new drug in the correction of simulated potentiopausal osteoporosis.


Key words

experimental postmenopausal osteoporosis, succinic acid salts, anti-osteoporotic agent.





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