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Vol. 21, Art. 57 (pp. 704-710)    |    2020       

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Experimental study of coagultion hemostasis in the development of an acute respiratory distress-syndrome of toxic etiology

State Scientific-research Test Institute of the Military Medicine, Russian Federation Defense Ministry, Saint-Petersburg, Russia.

Brief summary

In an experimental model of a lipopolysaccharide-induced acute respiratory distress-syndrome in rats the coagulation hemostasis during the first day following exposure has been studied. It has been found that acute respiratory distress-syndrome is accompanied by activation of extrinsic pathway of blood coagulation, hyperfibrinogenemia, elevated level of soluble fibrin monomer complexes and tendency to natural anticoagulant activity suppression. The findings are significant for justification of anticoagulant therapy of hemostatic disorders in acute respiratory distress-syndrome and for development of laboratory diagnostics methods.


Key words

acute respiratory distress syndrome, pulmonotoxicity, lipopolysaccharide, hemostasis, blood clotting tests, hypercoagulation, early diagnostics.

Reference list

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Reference


1. Angelini D.J. et al. Chemical warfare agent and biological toxin-induced pulmonary toxicity: could stem cells provide potential therapies? / Inhal. Toxicol. 2013. Vol. 25, N 1. P. 37-62. doi: 10.3109/08958378.2012.750406


2. Máca, J. et al. Past and present ARDS mortality rates: a systematic review / Respiratory care. 2017. Vol. 62, N 1. P. 113-122. doi: 10.4187/respcare.04716


3. Camprubí-Rimblas M. et al. Anticoagulant therapy in acute respiratory distress syndrome / Ann. Transl. Med. 2018. Vol. 6, N 2. P. 36. doi: 10.21037/atm.2018.01.08


4. Blondonnet R., Constantin J.M., Sapin V., Jabaudon M. Pathophysiologic approach to biomarkers in acute respiratory distress syndrome / Dis. Markers. 2016. Vol. 2016. ID 3501373. doi:10.1155/2016/3501273


5. Sinkov S.V., Zabolotskikh I.B., Shaposhnikov S.A., Fedorenko A.A. Implication of Acute Lung Injury in the Pathogenesis of Hemostatic Disorders. Obshhaja reanimatologija=General Reanimatology / 2008. Vol. 4, N 3. P. 9-13. [In Russian]. doi: 10.15360/1813-9779-2012-3-9


6. Millar F.R. et al. The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities / Thorax. 2016. Vol. 71, N 5. P. 462-473. doi: 10.1136/thoraxjnl-2015-207461


7. Potey P.M., Rossi A.G., Lucas C.D., Doward D.A. Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential / J Pathol. 2019. Vol. 247, N 5. P. 672-685. doi: 10.1002/path.5221