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Vol. 21, Art. 46 (pp. 570-578)    |    2020       

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Immunopatophysiological aspects of carbon tetrachloride effect

1Ural Federal University Named After the First President of Russia B.N. Yeltsin,
Yekaterinburg, Russian Federation
2Institute of Immunology and Physiology of the Ural Branch of the RAS, Yekaterinburg,
Russian Federation
3Federal State Budget Educational Institution of Higher Education «Ural state medical university» of the ministry of health of the Russian Federation, Yekaterinburg,
Russian Federation

Brief summary

Exposure to hepatotropic poison, carbon tetrachloride (CCl4) leads to the development of an acute inflammatory reaction in the liver tissue, which is accompanied by a quick increase in the number of T-lymphocytes in the blood vessel region and in the organ parenchyma. Inhibition of B-cell immunity is expressed by decrease in the number of CD45RA+ cells in the liver parenchyma. In the peripheral organ of the immune system, the spleen, the number of CD3+ cells increases in the early stages after CCl4 intoxication, and a sharp increase in the number of CD45RA+ is noted in the thymus. The use of an immunomodulator aminophthalhydrazide (APH) helps to reduce the excessive amount of T-lymphocytes and normalizes the number of B-lymphocytes in the damaged liver, thymus and spleen - it stimulates lymphopoiesis, which is expressed as an increase in the number of T- and B-lymphocytes in the parenchyma of the organs of the immune system.


Key words

toxic damage, carbon tetrachloride, lymphocytes, liver, thymus, spleen.

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