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Vol. 21, Art. 43 (pp. 534-549)    |    2020       

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Radiation-induced changes in the content of nuclear dna in brain neurons during prolonged radiation exposure

Voronezh State Institute of Physical Training
State Research Center - Burnasyan Federal Medical Biophysical Center
Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia
Military Training and Scientific Center of the Air Force "Air Force Academy named after Professor N.E. Zhukovsky and Yu.A. Gagarin"

Brief summary

. In the conducted research, it is shown that prolonged gamma irradiation in total doses up to 1 Gy has a stochastic effect on the size of neuronal nuclei and the content of nuclear DNA that does not have a dose and time dependence and does not cause significant organic changes in nerve cells. At the same time, the dynamics of changes in the size of neuronal nuclei and the content of DNA in them fluctuates around the norm, usually within insignificant limits. At the same time, in some periods of observation, changes in karyometric parameters and the content of nuclear DNA in neurons are borderline, when they are not quite normal, but not yet pathological. It is likely that with an increase in the radiation dose or the effect of concomitant harmful and dangerous environmental factors, changes in the size of nuclei and the content of nuclear DNA in brain neurons will become more pronounced and unidirectional.


Key words

radiobiological experiment, rats, small doses of radiation, brain, neurons, nuclear DNA.

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