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Vol. 21, Art. 31 (pp. 377-395)    |    2020       

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Resources and bioindication methods of "small doses" of radiation influence on the human body: modern state of the problem (analytical review)

Military Medical Academy named by C.M. Kirov

Brief summary

Cytogenetic (analysis of chromosomal aberrations, EPR spectroscopy, individual in situ fluorescence hybridization, micronuclear test) and hematological parameters (absolute and relative lymphopenia) remain the most important indicators of the damaging effects of ionizing radiation on the body. A number of methods have been developed to assess the immune status affected by "small" doses. A new direction of bioindication of radiation-induced effects is successfully developing: genomics (gene expression), proteomics (content and biological activity of protein products), metabolomics (metabolites that occur when biomolecules are damaged), transcriptomics (changes in the composition of ribonucleic acids).


Key words

bioindication, ionizing radiation, "small" doses, hematological, cytogenetic, immunological indicators; genomics, metabolomics.

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