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Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




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199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

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«
Vol. 21, Art. 13 (pp. 141-156)    |    2020       
»

Reasons for high lethality in overdose of drugs from the group of synthetic opioids
«Institute of Toxicology» of Federal Medico-Biological Agency of Russia



Brief summary

Synthetic opioids are superior to opium alkaloids in acute toxicity, analgesic, addictogenic potentials, ability to inhibit the respiratory center, cause rigidity of the respiratory muscles and muscles of the larynx. Heroin addicts lack cross-tolerance for respiratory depression caused by synthetic opioids. Respiratory depression and its subsequent stopping develop in few minutes, when medical care is usually unavailable. In acute poisoning with fentanyl and its derivatives, naloxone is less effective than in case of poisoning with opiates. These peculiarities of the toxicity of psychotropic substances from the group of opioids synthesized with the aim of circumventing the current legislation, determine the high lethality in case of their overdose.


Key words

opioids, overdoses, toxicity, mortality, lethality.





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