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Vol. 20, Art. 4 (pp. 36-43)    |    2019       

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Unaccounted anaphylactic reaction to effect of mycotoxins

Semenov E.I., Mishina N.N., Papunidi K.Kh.,

Federal Center for Toxicological, Radiation and Biological Safety

Brief summary

In an experiment influence of the combined mikotoksikoz on the course of reaction of a system anaphylaxis at rats, sensibilized by model allergen - chicken ovalbumin is studied. For 30 days of a rat received a forage kontaminirovanny T-2 mycotoxins toxin and desoxynivalenol separately and combined in doses at the levels maximum allowed. Degree of a sensitization was estimated on accumulation of antibodies of class G in reaction of an indirect solid-phase enzyme immunoassay. Barrier function of intestines on high-molecular connections was investigated on increase in permeability of a wall of a small intestine for polyethyleneglycol 4000. As a result of an experiment established that under the influence of mycotoxins in low doses there is an increase in allergic reaction to other allergens (ovalbumin, xenobiotics) and also disturbance of barrier function of intestines. The received results partially explain the reasons of clinical implication of an allergosis (short wind, cough, bronchial pneumonia, an eosinophilia, eosinophilic infiltration mucous intestines) at a latent current of a mikotoksikoz.


Key words

mycotoxins, T-2 toxin, desoxynivalenol, allergy, anaphylaxis.

Reference list

1. Hussein, S. Toxicity, metabolism, and impact of mycotoxins on humans and animals / S. Hussein, M. Brasel // Toxicology. - 2001. - Vol. 167. - P. 101-134.


2. Mikotoksini (v pishevoi cepochke): monografiya. / K.H. Papynidi [i dr.]; pod red. K.H. Papynidi. - 2-e izd., pererab. i dop. Kazan: FGBNY «FCTRB-VNIVI»; 2017.


3. Sato, N. Toxicological approaches to the toxic metabolites of Fusaria VIII: acute and subacute toxicities of T-2 toxin in cats / N. Sato, Y. Ueno, M. Enomoto // Japan. J. Pharmacol. - 1975. - Vol. 25. - P. 263-270.


4. Smith, T.K. Recent advances in the understanding of Fusarium trichothecene mycotoxicoses / T.K.Smith // J. Anim. Sci. - 1992. - V. 70. - P. 3989-3993


5. Bergers, W. Changes in circulatory white blood cells of mice and rats due to acute trichothecene intoxication / W. Bergers, E. Van Dura, J. Van Der Stap // Tox. Lett. - 1987. - V. 36. - P. 173-179.


6. Semenov, E.I. Joint effect of the mycotoxins T-2 toxin, deoxynivalenol and zearalenone on the weaner pigs against a background of the infection load / E.I. Semenov, L.E. Matrosova, M.Ya. Tremasov, E.Yu. Tarasova et al.// Research Journal of Pharmaceutical, Biological and Chemical Sciences. - 2016. - V. 7. - ? 1. - P. 1860-1868.


7. Papunidi, K.Kh. Cytomorphological shanges hepatorenal system combined with fever poisoning xenobiotics / K.Kh. Papunidi, I.R. Kadikov, V.R. Saitov, M.Ya. Tremasov, A.M. Tremasova et al. // Research Journal of Pharmaceutical, Biological and Chemical Sciences. - 2016. - V. 7. - ? 4. - P. 2214-2220.


8. Semenov, E.I. Efficiency of application of a polysaccharide enterosorbent of «Fitosorb» for prevention of the combined mycotoxicosis / E.I. Semenov, A.M. Tremasova, V.R. Saitov, S.Yu. Smolentsev, F.A. Sunagatullin et al. // Research Journal of Pharmaceutical, Biological and Chemical Sciences. - 2016. - V. 7. - ? 4. - P. 2229-2237.


9. Papunidi, K.Kh. Homeostatic system of sheep against the background of combined effects of pollutants and the use of therapeutic and preventive agents / K.Kh. Papunidi, I.R. Kadikov, V.R. Saitov, E.I. Semenov, D.K. Gataullin, A.A. Korchemkin, A.M. Tremasova // Bali Medical Journal. - 2017. - V. 6. - ? 2. - P. 83-87.


10. Smith, M.C. Natural co-occurrence of mycotoxins in foods and feeds and their in vitro combined toxicological effects / M.C. Smith, S. Madec, E. Coton, N. Hymery // Toxins. - 2016. - V. 8. - ? 4. - P. 94.


11. Bondy, G.S. Immunomodulation by fungal toxins. / G.S. Bondy, J.J Pestka // J. Toxicol. Environ. Health. Critical Reviews (Parth B). - 2000. - ?3 - P. 109-143.


12. Corrier, D. Mycotoxicosis: mechanisms of immunosuppression / D. Corrier // Vet. Immunopathol. - 1991. - V. 30. - P. 73-87.


13. Rotter B., Thompson B., Lessard M. et al. Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine // Fund. Appl. Toxicol. - 1994. - V. 23. - P. 117-124.


14. Semenov, E.I. Screening drugs-potential immunomodulators for T-2 mycotoxicosis / E.I. Semenov, N.N. Mishina, I.R. Kadikov, S.Y. Smolentsev, A.I. Nikitin, K.Kh. Papunidi, M.Ya. Tremasov // Bali Medical Journal. - 2017. - V. 6. - ? 2. - P. 110-114.


15. Vidal, D. Proprietes immunosuppressives des mycotoxines du groupe des trichothecenes / D. Vidal // Bull. Inst. Pacteur. - 1990. - ?88. - P. 159-182.


16. Stokes, C.R. Animal models of food sensitivity / C.R. Stokes, B.G. Miller, F.J. Bourne // Food allergy and intolerance. London e.a. - 1987. - P. 286-300.


17. Gmoshinskii, I.V. Opredelenie antitel klassa IgG y eksperimentalnih jivotnih, sensibilizirovannih peroralno pishevim belkom (k harakteristike modeli pishevoi anafilaksii) / I.V.Gmoshinskii, V.V. Krjechkovskaya, N.N. Pyatnickii // Voprosi pitaniya. - 1994. - ?1-2. - S. 30-33.


18. Ocenka bezopasnosti nanomaterialov: Metodicheskie rekomendacii.?M: FGYZ "Federalnii centr gigieni i epidemiologii" Federalnoi slyjbi po nadzory v sfere zashiti prav potrebitelei i blagopolychiya cheloveka, 2007. - Rejim dostypa: http://gost.donses.ru/Data1/52/52003/index.htm, svobodnii.