Federal state budgetary institution «National Medical and Surgical Center named after N.I. Pirogov» of the Ministry of Healthcare of the Russian Federation.
Brief summary
Biological therapies have attracted more and more attention in recent decades. To date, in medicine, widespread therapies based on the use of autologous blood plasma (ABP). In this study, a biological analysis of platelet-rich plasma was performed. obtained using tubes for ABP-therapy of two types. In the first group, test tubes were used to obtain PRP, in the second to obtain ACP.
The study showed that when choosing tubes for PRP therapy, it is important to take into account the centrifugation mode and the plasma selection system, preferring closed systems that allow to obtain pure ABP, preserve sterility and reduce the risks of contamination of biomaterial with a minimum number of manipulations. In particular, the therapy of inflammatory nosologies requires the use of PRP, which may determine the possibility of correcting the local immune status. In cavity operations in ophthalmology, it is advisable to use ACP, which has a low response from the immune system. The main role of APC in this case tamponade tissue defect due to the properties of the material used.
1. Arsutov D.G. Ispolzovanie aytologichnoi kondicionirovannoi plazmi, obogashennoi trombocitami, v hiryrgii regmatogennoi otsloiki setchatki s centralnim i perifericheskimi razrivami // Acta Biomedica Scientifica. - 2019. - Tom 4. - 4.
2. Ahmerov R., Zarydii R., Richkova I. s soavt. Plazmolifting (Plasmolifting). Lechenie vozrastnoi atrofii koji bogatoi trombocitami aytoplazmoi // Esteticheskaya medicina. - 2011. - ? 2. - S. 181-187.
3. Achkasov E.E., Bezyglov E.N., Ylyanov A.A. s soavt. Primenenie aytoplazmi, obogashennoi trombocitami, v klinicheskoi praktike // Biomedicina. - 2013. - 4. - S. 46-59.
8. Faizrahmanov R.R. Pavlovskii O.A., Larina E.A. Hiryrgicheskoe lechenie pacientov s neystranennim makylyarnim razrivom // Vestnik Nacionalnogo mediko-hiryrgicheskogo Centra im. N.I. Pirogova.- 2019. 14 (2).- S. 98-104. DOI: 10.25881/BPNMSC.2018.64.37.021.
9. Shpak A.A., Shkvorchenko D.O., Krypina E.A. Stryktyrnie izmeneniya makylyarnoi oblasti posle hiryrgicheskogo lecheniya makylyarnih razrivov s primeneniem bogatoi trombocitami plazmi krovi // Oftalmohiryrgiya. - 2018. - 4. - S. 52-57.
10. Anitua E. et al. Preservation of biological activity of plasma and platelet-derived eye-drops after their different time and temperature conditions of storage // Cornea. - 2015. - Vol. 34. - 9. - R. 1144 - 1148].
11. Arshdeep K., Kumaran M. Platelet-rich plasma in dermatology: Boon or a bane? // Ind J Dermatol Venereol Leprol. - 2014. - Vol. 80. - R. 5-14.
12. Dragonas P., Katsaros T., Avila-Ortiz G. et. al. Effects of leukocyte-platelet-rich fibrin (L-PRF) in different intraoral bone grafting procedures: a systematic review // Int J Oral Maxillofac Surgery.- 2019 Vol. 48. - 2. - R. 250 -262.
13. Ehrenfest D.M., Bielecki T., Mishra A., et. al. In search of a consensus terminology in the field of platelet concentrates for surgical use: plateletrich plasma (PRP), platelet-rich fibrin (PRF), fibrin gel polymerization and leukocytes // Current pharmaceutical biotechnology. - 2012. - Vol. 13. - 7 - R.1131-1137
14. Soldatova L., Campbell R.G., Elkhatib A.H. et. al. Role of Leukocyte-Platelet-Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction // J Neurol Surgery Skull Base. - 2017. Vol. 78. - 1 - R.59-62 DOI: 10.1055/s-0036-1584894.
15. Yang B., Houlberg K., Millward A. et. al. Polymorphisms of chemokine and chemokine receptor genes in Type 1 diabetes mellitus and its complications // Cytokine. - 2004 Vol. 7. - 26 - R.114-121.