Медико-биологический
информационный портал
для специалистов
 
Medline.ru

СОДЕРЖАНИЕ ЖУРНАЛА:
Физико-химическая биология

Клиническая медицина

Профилактическая медицина

Медико-биологические науки


АРХИВ:

Фундаментальные исследования

Организация здравохраниения

История медицины и биологии



Последние публикации

Поиск публикаций

Articles

Архив :  2000 г.  2001 г.  2002 г. 
               2003 г.  2004 г.  2005 г. 
               2006 г.  2007 г.  2008 г. 
               2009 г.  2010 г.  2011 г. 
               2012 г.  2013 г.  2014 г. 
               2015 г.  2016 г.  2017 г. 
               2018 г.  2019 г.  2020 г.  2021 г.  2022 г.  2023 г. 

Редакционная информация:
        Опубликовать статью
        Наша статистика


 РЕДАКЦИЯ:
Главный редактор

Заместители главного редактора

Члены редколлегии
Специализированные редколлегии


 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
Искать: 


«
Vol. 20, Art. 19 (pp. 211-228)    |    2019       
»

Pulmotoxic effect of pyrolysis products of chlorine-containing polymer materials (literature review)
Potapov P.K., Tolkach P.G., Basharin V.A., Sizova D.T., Lopatko V.S.

Military Medical Academy. S.M. Kirov



Brief summary

In the modern world, natural materials are being replaced by their artificial counterparts. When they burn, due to emergencies accompanied by fires, a large number of various toxic compounds are released, the inhalation effect of which will have a toxic effect on the victims. Among the polymeric materials, chlorine-containing compounds are widely used, during the pyrolysis of which a large amount of carbon monoxide and hydrogen chloride will be released into the atmosphere of fire. The article describes the toxic effects of the products of the pyrolysis of chlorine-containing polymer materials on the victims. It is indicated that the combined effect of carbon monoxide and hydrogen chloride will lead to the development of mixed hypoxia due to a violation of the oxygen transport function of the blood and a decrease in oxygen diffusion through the alveolar-capillary membrane. Studying the characteristics of the combined effects of the products of the pyrolysis of chlorine-containing materials on the victims is essential for planning and providing medical care, in order to preserve life and professional performance.


Key words

fire, polyvinyl chloride, flame retardants, hydrogen chloride, carbon monoxide, pulmonotoxicity, acute pulmonary edema, hypoxia.





(The article in PDF format. For preview need Adobe Acrobat Reader)



Open article in new window

Reference list

1. Analiz obstanovki s pojarami i posledstviya ot nih na territorii Rossiiskoi Federacii za 2018 god / MChS Rossii. Departament nadzornoi deyatelnosti. - M., 2018.


2. Vasileva, O. S. Ostrie toksicheskie porajeniya dihatelnih pytei / O.S. Vasileva // Medicinskii vestnik Bashkortostana. - 2010. - T. 5, ? 1.


3. Zobnin, U. V. Otravlenie monooksidom ygleroda (ygarnim gazom) / U. V. Zobnin [i dr.]; naych. red. U. V. Zobnin. - SPb.: Taktik-Stydio, 2011. - 86 s.


4. Ilichkin, V. S. Opredelenie pokazatelya toksichnosti prodyktov goreniya materialov eksperimentalno-raschetnim metodom / V. S. Ilichkin [i dr.] // Pojarovzrivobezopasnost. - 2005. - T. 14. - N 3.


5. Kassil, V. L. Ostrii respiratornii distress - sindrom / V. L. Kassil, E. S. Zolotokrilina. - M.: Medicina, 2006.


6. Leonova, D. I. Identifikaciya komponentov prodyktov goreniya polivinilhloridnih materialov / D. I. Leonova, M. R. Kopa, N. G. Selivanenko //Aktyalnie problemi transportnoi medicini. - 2006.


7. Madorskii, S. L. Termicheskoe razlojenie organicheskih polimerov: Per. s angl. / C. L. Madorskii [i dr.]. - Mir, 1967.


8. Mogosh, G. Ostrie otravleniya / G. Mogosh. - Byharest, 1984. - 580 s.


9. Polivinilhlorid (PVH): osnovnie svoistva, oblast primeneniya [Elektronnii resyrs]. - Rejim dostypa: http:// plastinfo.ru/information/articles/38/ (data obrasheniya - 12.07.2019).


10. Pyzach, S. V. Osobennosti tanatogeneza smerti cheloveka, pogibshego na pojare / S. V. Pyzach, A. V. Smagin, V. M. Doan //Tehnologii tehnosfernoi bezopasnosti. - 2008. - N 5. - S. 5-5.


11. Rassledovanie gibeli moryakov na glybokovodnom apparate VMF [Elektronnii resyrs]. - Rejim dostypa: https://tass.ru/proisshestviya/6622222 (data obrasheniya 04.07.2019 g.).


12. Savickii, N. N. Chastnaya patologiya i terapiya porajenii boevimi otravlyaushimi veshestvami / N. N. Savickii // Rykovodstvo dlya vrachei. - Medgiz, 1939.


13. Savchenkova E. E. Analiz toksichnosti prodyktov goreniya pri pojare / E. E. Savchenkova, P. A. Battalova. - 2017.


14. Smetannikova, A. P. Vozdeistvie prodyktov goreniya plastmass na organizm cheloveka / A. P. Smetannikova // Novaya nayka: Ot idei k rezyltaty. - 2016. - N. 12-4. - S. 213-215.


15. Sofronov, G.A. Kachestvo jizni lic, perenesshih ostrie otravleniya prodyktami goreniya / G. A. Sofronov, V. S. Chernii, M. V. Aleksandrov // Vestn. Ros. Voen.-med. akad. - 2012. - T. 2, N 38. - S. 6-10.


16. Sire i dobavki // «Plastiks». - N 8 (148). - C. 17.


17. Torkynov, P.A. Toksicheskii otek legkih: patogenez, modelirovanie, metodologiya izycheniya / P.A Torkynov, P.D. Shabanov // Obzori po klinicheskoi farmakologii i lekarstvennoi terapii. - 2008. - T. 6, N 2. - S. 3-54.


18. Tryshkin, D. V. Ocenka pojarnoi opasnosti stroitelnih materialov na osnove analiza dinamicheskih harakteristik. Toksichnost letychih prodyktov goreniya, vosplamenyaemost i rasprostranenie plameni D. V. Tryshkin // Pojarovzrivobezopasnost. - 2003. - T. 12. - N 1.


19. Federalnii zakon ot 22.07.2008 ?123-FZ (red. ot 03.07.2016) Tehnicheskii reglament o trebovaniyah pojarnoi bezopasnosti. - S. 7-8.


20. ARDS Definition task forces. Acute respiratory distress syndrome. The Berlin Definition // JAMA. - 2012. - Vol. 307, N 23. - P. 2526-2533.


21. Baxter, P. J. Thetford plastics fire, October 1991: the role of a preventive medical team in chemical incidents / P. J. Baxter [et al.] // Occupational and environmental medicine. - 1995. - Vol. 52, N 10. - P. 694-698.


22. Boettner, E. A. Analysis of the volatile combustion products of vinyl plastics / E. A. Boettner, G. Ball, B. Weiss // Journal of applied polymer science. - 1969. - Vol. 13, N 2. - P. 377-391.


23. Burleigh-Flayer, H. Evaluation of the pulmonary effects of HCl using CO2 challenges in guinea pigs / H. Burleigh-Flayer, K. L. Wong, Y. Alarie // Toxicological Sciences. - 1985. -Vol. 5, N 5. - P. 978-985.


24. Colardyn, F. Acute inhalation-intoxication by combustion of polyvinylchloride / F. Colardyn [et al.] // International archives of occupational and environmental health. - 1976. - Vol. 38, N 2. - P. 121-127.


25. Cox, R. A. Upper airway mucus deposition in lung tissue of burn trauma victims. R. A. Cox [et al.] // Shock. - 2008. - Vol. 29, N 3. - P. 356-361.


26. Demling, R. H. Smoke inhalation lung injury: an update / R. H. Demling // Eplasty. - 2008. - P. 8.


27. Doe, J. E. The combustion toxicology of polyvinylchloride revisited / J. E. Doe // Journal of fire sciences. - 1987. - Vol. 5, N 4. - P. 228-247.


28. Duniho, S.M. Acute changes in lung histopathology and bronchoalveolar lavage parameters in mice exposed to the choking agent gas phosgene / S.M Duniho, J. Martin, J.S Forster [et al.] // Toxicologic pathology. - 2002. - Vol. 30, N 3. - P. 339-349.


29. Foncerrada, G. Inhalation Injury in the Burned Patient / G. Foncerrada [et al.] // Annals of plastic surgery. - 2018. - Vol. 80, N 3. - P. 98-105.


30. Froneberg, B. Respiratory illness caused by overheating of polyvinyl chloride / B. Froneberg, P. L. Johnson, P. J. Landrigan // Occupational and Environmental Medicine. - 1982. - Vol. 39, N 3. - P. 239-243.


31. Gorguner, M. Acute inhalation injury / M. Gorguner, M. Akgun //The Eurasian journal of medicine. - 2010. - Vol. 42, N 1. - S. 28.


32. Gupta, K. Smoke inhalation injury: Etiopathogenesis, diagnosis, and management / K. Gupta [et al.] // Indian journal of critical care medicine: peer-reviewed, official publication of Indian Society of Critical Care Medicine. - 2018. - Vol. 22, N 3. - P. 180.


33. Lange, M. Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury / M. Lange [et al.] // Crit Care Med. - 2011. - Vol. 39, N 4. - P. 718-724.


34. Markowitz, J. S. Self-reported short-and long-term respiratory effects among PVC-exposed firefighters / J. E. Markowitz // Archives of Environmental Health: An International Journal. - 1989. - Vol. 44, N 1. - S. 30-33.


35. Nakae, H. Failure to clear casts and secretions following inhalation injury can be dangerous: report of a case / H. Nakae, H. Tanaka, H. Inaba // Burns. - 2001. - N 27 (2). - P. 189-191.


36. Napier, D. H. Hazardous materials and the gases they produce / D. H. Napier // Medicine, Science and the Law. - 1977. - Vol. 17, N 2. - P. 83-90.


37. Packham, S. C. Fundamentals of combustion toxicology in fire hazard assessment / S. C. Packham, G. E. Hartzell // Journal of Testing and Evaluation. - 1981. - Vol. 9, N 6. - P. 341-347.


38. Penney, D. G. Carbon monoxide poisoning / D. G. Penney. - New York, 2008. - P. 812.


39. Rosenthal, T. Poisoning caused by inhalation of hydrogen chloride, phosphorus oxychloride, phosphorus pentachloride, oxalyl chloride, and oxalic acid / T. Rosenthal [et al.] // Chest. - 1978. - Vol. 73, N 5. - P. 623-626.


40. Selected causes of death. Worldlifeexpectancy [sait] URL: http://www.worldlifeexpectancy.com/ (data obrasheniya 29.08.2019).


41. Silva, L. Acute respiratory distress syndrome in burn patients: incidence and risk factor analysis / L. Silva [et al.] // Annals of burns and fire disasters. - 2016. - Vol. 29, N 3. - P. 178.


42. Solway, J. Sensory neuropeptides and airway function / J. Solway, A. R. Leff // Appl Physiol. - 1991. - Vol. 71, N 6. - P. 2077-2087.


43. Substances, elements, chemical agents / The National Institute for Occupational Safety and Health [Elektronnii resyrs]. - Rejim dostypa: httsp://cdc.gov/niosh/ (data obrasheniya: 12.08.2019 g.).


44. Van Mourik, L. M. Chlorinated paraffins in the environment: A review on their production, fate, levels and trends between 2010 and 2015 / L. M. Van Mourik [et al.] // Chemosphere. - 2016. - N 155. - P. 415-428.


45. Wang, W. Quality improvement of pyrolysis oil from waste rubber by adding sawdust / W. Wang [et al.] // Waste Manag. - 2014. - N 34 (12). - P. 2603- 2610.


46. Wheeler, A.P. Acute lung injury and the acute respiratory distress syndrome: a clinical review / A.P. Wheeler, G.R. Bernard // The Lancet. - 2007. - Vol. 369, N 9572. - P. 1553-1564.


47. White, C.V. Chlorine gas inhalation: human clinical evidence of toxicity an experience in animal models / C. V. White, J. G. Martin // Proc. Am. Thorac. Soc. - 2010. - N 7 (4). - P. 257-263.


48. Wilken, J. A. Exposures and symptoms among workers after an offsite train derailment and vinyl chloride release / J. A. Wilken [et al.] // American journal of disaster medicine. - 2015. - Vol. 10, N 2. - P. 153.


49. World fire statistics: Information bulletin of the World Fire Statistics Centre. - Jeneva, 2018. - N 23.





Referenses


1. Analiz obstanovki s pozharami i posledstvija ot nih na territorii Rossijskoj Federacii za 2018 god / MChS Rossii. Departament nadzornoj dejatel'nosti. - M., 2018.


2. Vasil'eva, O. S. Ostrye toksicheskie porazhenija dyhatel'nyh putej / O.S. Vasil'eva // Medicinskij vestnik Bashkortostana. - 2010. - T. 5, N 1.


3. Zobnin, Ju. V. Otravlenie monooksidom ugleroda (ugarnym gazom) / Ju. V. Zobnin [i dr.]; nauch. red. Ju. V. Zobnin. - SPb.: Taktik-Studio, 2011. - 86 s.


4. Ilichkin, V. S. Opredelenie pokazatelja toksichnosti produktov gorenija materialov jeksperimental'no-raschetnym metodom / V. S. Ilichkin [i dr.] // Pozharovzryvobezopasnost'. - 2005. - T. 14. - N 3.


5. Kassil', V. L. Ostryj respiratornyj distress - sindrom / V. L. Kassil', E. S. Zolotokrylina. - M.: Medicina, 2006.


6. Leonova, D. I. Identifikacija komponentov produktov gorenija polivinilhloridnyh materialov / D. I. Leonova, M. R. Kopa, N. G. Selivanenko //Aktual'nye problemy transportnoj mediciny. - 2006.


7. Madorskij, S. L. Termicheskoe razlozhenie organicheskih polimerov: Per. s angl. / C. L. Madorskij [i dr.]. - Mir, 1967.


8. Mogosh, G. Ostrye otravlenija / G. Mogosh. - Buharest, 1984. - 580 s.


9. Polivinilhlorid (PVH): osnovnye svojstva, oblast' primenenija [Jelektronnyj resurs]. - Rezhim dostupa: http:// plastinfo.ru/information/articles/38/ (data obrashhenija - 12.07.2019).


10. Puzach, S. V. Osobennosti tanatogeneza smerti cheloveka, pogibshego na pozhare / S. V. Puzach, A. V. Smagin, V. M. Doan //Tehnologii tehnosfernoj bezopasnosti. - 2008. - N 5. - S. 5-5.


11. Rassledovanie gibeli morjakov na glubokovodnom apparate VMF [Jelektronnyj resurs]. - Rezhim dostupa: https://tass.ru/proisshestviya/6622222 (data obrashhenija 04.07.2019 g.).


12. Savickij, N. N. Chastnaja patologija i terapija porazhenij boevymi otravljajushhimi veshhestvami / N. N. Savickij // Rukovodstvo dlja vrachej. - Medgiz, 1939.


13. Savchenkova E. Je. Analiz toksichnosti produktov gorenija pri pozhare / E. Je. Savchenkova, P. A. Battalova. - 2017.


14. Smetannikova, A. P. Vozdejstvie produktov gorenija plastmass na organizm cheloveka / A. P. Smetannikova // Novaja nauka: Ot idei k rezul'tatu. - 2016. - N. 12-4. - S. 213-215.


15. Sofronov, G.A. Kachestvo zhizni lic, perenesshih ostrye otravlenija produktami gorenija / G. A. Sofronov, V. S. Chernyj, M. V. Aleksandrov // Vestn. Ros. Voen.-med. akad. - 2012. - T. 2, N 38. - S. 6-10.


16. Syr'e i dobavki // «Plastiks». - ? 8 (148). - C. 17.


17. Torkunov, P.A. Toksicheskij otek legkih: patogenez, modelirovanie, metodologija izuchenija / P.A Torkunov, P.D. Shabanov // Obzory po klinicheskoj farmakologii i lekarstvennoj terapii. - 2008. - T. 6, N 2. - S. 3-54.


18. Trushkin, D. V. Ocenka pozharnoj opasnosti stroitel'nyh materialov na osnove analiza dinamicheskih harakteristik. Toksichnost' letuchih produktov gorenija, vosplamenjaemost' i rasprostranenie plameni D. V. Trushkin // Pozharovzryvobezopasnost'. - 2003. - T. 12. - N 1.


19. Federal'nyj zakon ot 22.07.2008 ?123-FZ (red. ot 03.07.2016) Tehnicheskij reglament o trebovanijah pozharnoj bezopasnosti. - S. 7-8.


20. Acute Respiratory Distress Syndrome. JAMA. 2012;307(23). doi:10.1001/jama.2012.5669


21. Baxter P, Heap B, Rowland M, Murray V. Thetford plastics fire, October 1991: the role of a preventive medical team in chemical incidents. Occup Environ Med. 1995;52(10):694-698. doi:10.1136/oem.52.10.694


22. Baxter P, Heap B, Rowland M, Murray V. Thetford plastics fire, October 1991: the role of a preventive medical team in chemical incidents. Occup Environ Med. 1995;52(10):694-698. doi:10.1136/oem.52.10.694


23. Boettner E, Ball G, Weiss B. Analysis of the volatile combustion products of vinyl plastics. J Appl Polym Sci. 1969;13(2):377-391. doi:10.1002/app.1969.070130211


24. Colardyn F, van der Straeten M, Lamont H, van Peteghem T. Acute inhalation-intoxication by combustion of polyvinylchloride. Int Arch Occup Environ Health. 1976;38(2):121-127. doi:10.1007/bf00378622


25. Cox R, Mlcak R, Chinkes D et al. UPPER AIRWAY MUCUS DEPOSITION IN LUNG TISSUE OF BURN TRAUMA VICTIMS. Shock. 2007:1. doi:10.1097/shk.0b013e31814541dd


26. Demling, R. H. Smoke inhalation lung injury: an update / R. H. Demling // Eplasty. - 2008. - P. 8.


27. Doe J. The Combustion Toxicology of Polyvinylchloride Revisited. J Fire Sci. 1987;5(4):228-247. doi:10.1177/073490418700500402


28. Duniho S, Martin J, Forster J et al. Acute Changes in Lung Histopathology and Bronchoalveolar Lavage Parameters in Mice Exposed to the Choking Agent Gas Phosgene. Toxicol Pathol. 2002;30(3):339-349. doi:10.1080/01926230252929918


29. Foncerrada G, Culnan D, Capek K et al. Inhalation Injury in the Burned Patient. Ann Plast Surg. 2018:1. doi:10.1097/sap.0000000000001377


30. Froneberg B, Johnson P, Landrigan P. Respiratory illness caused by overheating of polyvinyl chloride. Occup Environ Med. 1982;39(3):239-243. doi:10.1136/oem.39.3.239


31. Gorguner M, Akgun M. Acute Inhalation Injury. Eurasian J Med. 2010;42(1):28-35. doi:10.5152/eajm.2010.09


32. Gupta K, Mehrotra M, Kumar P, Gogia A, Prasad A, Fisher J. Smoke Inhalation Injury: Etiopathogenesis, Diagnosis, and Management. Indian Journal of Critical Care Medicine. 2018;22(3):180-188. doi:10.4103/ijccm.ijccm_460_17


33. Lange M, Hamahata A, Traber D et al. Preclinical evaluation of epinephrine nebulization to reduce airway hyperemia and improve oxygenation after smoke inhalation injury*. Crit Care Med. 2011;39(4):718-724. doi:10.1097/ccm.0b013e318207ec52


34. Markowitz J. Self-Reported Short- and Long-Term Respiratory Effects among PVC-Exposed Firefighters. Archives of Environmental Health: An International Journal. 1989;44(1):30-33. doi:10.1080/00039896.1989.9935869


35. Nakae H, Tanaka H, Inaba H. Failure to clear casts and secretions following inhalation injury can be dangerous: report of a case. Burns. 2001;27(2):189-191. doi:10.1016/s0305-4179(00)00100-5


36. Napier D. Hazardous Materials and the Gases They Produce. Medicine, Science and the Law. 1977;17(2):83-90. doi:10.1177/002580247701700203


37. Packham, S. C. Fundamentals of combustion toxicology in fire hazard assessment / S. C. Packham, G. E. Hartzell // Journal of Testing and Evaluation. - 1981. - Vol. 9, N 6. - P. 341-347.


38. Penney, D. G. Carbon monoxide poisoning / D. G. Penney. - New York, 2008. - P. 812.


39. Rosenthal T, Baum G, Frand U, Molho M. Poisoning Caused by Inhalation of Hydrogen Chloride, Phosphorus Oxychloride, Phosphorus Pentachloride, Oxalyl Chloride, and Oxalic Acid. Chest. 1978;73(5):623-626. doi:10.1378/chest.73.5.623


40. Selected causes of death. Worldlifeexpectancy [sait] URL: http://www.worldlifeexpectancy.com/ (data obrasheniya 29.08.2019).


41. Silva, L. Acute respiratory distress syndrome in burn patients: incidence and risk factor analysis / L. Silva [et al.] // Annals of burns and fire disasters. - 2016. - Vol. 29, N 3. - P. 178.


42. Solway J, Leff A. Sensory neuropeptides and airway function. J Appl Physiol. 1991;71(6):2077-2087. doi:10.1152/jappl.1991.71.6.2077


43. Substances, elements, chemical agents / The National Institute for Occupational Safety and Health [Elektronnii resyrs]. - Rejim dostypa: httsp://cdc.gov/niosh/ (data obrasheniya: 12.08.2019 g.).


44. van Mourik L, Gaus C, Leonards P, de Boer J. Chlorinated paraffins in the environment: A review on their production, fate, levels and trends between 2010 and 2015. Chemosphere. 2016;155:415-428. doi:10.1016/j.chemosphere.2016.04.037


45. Wang W, Chang J, Cai L, Shi S. Quality improvement of pyrolysis oil from waste rubber by adding sawdust. Waste Management. 2014;34(12):2603-2610. doi:10.1016/j.wasman.2014.08.016


46. Wheeler A, Bernard G. Acute lung injury and the acute respiratory distress syndrome: a clinical review. The Lancet. 2007;369(9572):1553-1564. doi:10.1016/s0140-6736(07)60604-7


47. White C, Martin J. Chlorine Gas Inhalation: Human Clinical Evidence of Toxicity and Experience in Animal Models. Proc Am Thorac Soc. 2010;7(4):257-263. doi:10.1513/pats.201001-008sm


48. Wilken, PhD J, Graziano, BS L, Vaouli, MPH E et al. Exposures and symptoms among workers after an offsite train derailment and vinyl chloride release. Am J Disaster Med. 2015;10(2):153-165. doi:10.5055/ajdm.2015.0198


49. World fire statistics: Information bulletin of the World Fire Statistics Centre. - Jeneva, 2018. - N 23.





Свидетельство о регистрации сетевого электронного научного издания N 077 от 29.11.2006
Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций
(c) Перепечатка материалов сайта Medline.Ru возможна только с письменного разрешения редакции

Размещение рекламы

Rambler's Top100