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 УЧРЕДИТЕЛИ:
Институт теоретической и экспериментальной биофизики Российской академии наук.

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Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 19, Art. 49 (pp. 673-681)    |    2018       
»

Endogenous testosterone and long-term outcomes of coronary stenting in men with coronary heart disease
Makarova A.V.,1 Shustov S.B.,1,2 Kitsyshin V.P.,2 Vorokhobina N.V.1

1I.I. Mechnikov North-Western State Medical University, Saint Petersburg, Russia
2S.M. Kirov Military Medical Academy, Saint Petersburg, Russia



Brief summary

A total of 112 men with coronary heart disease 28-83 years of age (mean age of 60,8 - 6,6 years) were available for examination before planned coronary stenting. These patients were divided to a group with late-onset hypogonadism and a group without late-onset hypogonadism, age subgroups were also formed. Nineteen patients were 46-59 years old and presented confirmed late-onset hypogonadism (subgroup 1), 21 were 60-74 years old and had confirmed late-onset hypogonadism (subgroup 2), 37 men of 46-59 years and 35 men of 60-74 years had no hypogonadism (subgroup 3 and 4). We analyzed new major cardiovascular events (death from cardiovascular causes, myocardial infarction, stroke, recurrent heart revascularization, noncoronary artery stenting) in 4.4?1.8 years after myocardial revascularization. It was found that 46-59 years old patients with testosterone under 12 mmol/l had better long-term results of coronary stenting than men with normal testosterone of the same age (р<0,05). Long-term results were similar in patients in late adulthood with testosterone deficiency and without it. Hypotestosteronemia might have adaptive and protective role in middle age patients with high cardiovascular risk and coronary stenting in anamnesis.


Key words

coronary heart disease, stenting, male, late-onset hypogonadism, total testosterone, cardiovascular events.





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