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Vol. 19, Art. 4 (pp. 55-64)    |    2018       

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Role of polymorphisms of cytokine genes in the development of a protracted complicated course of nosocomial pneumonia in patients with polytrauma

Prokhorov A.V., Khalimov Y.S., Karamullin M.A., Zhekalov A.N.

The Ministry of Defense of Russian Federation S.M. Kirov Military Medical Academy, war therapy department

Brief summary

The intensity of systemic inflammatory response on polytrauma is associated with variants of cytokines genes polymorphism and tends to complicated and long-durated course of nosocomial pneumonia in traumatized payients. Goals and objectives. The investigation of TNFα G-308A and IL-10 GG (1082) haplotypes in traumatized patients with nosocomial pneumonia. Materials and methods. In prospective cohort study 122 patients after polytrauma (94 males and 28 females) were included and divided into 2 groups ? with and without nosocomial pneumonia in posrtraumatic period (62 and 60 respectively). The distribution of haplotypes TNFα G308-А (GA or АА) and IL-10 GG (1082) was studied. Results. Haplotypes TNFα G308-А (GA or АА) were more frequently in patients with nosocomial pneumonia after polytrauma. Haplotypes TNFα G308-А (GA or АА) and IL-10 GG (1082) were associated .with complicated and long-durated course of nosocomial pneumonia in traumatized payients. Conclusions. Identification of TNFα (308) and IL-10 (1082) genotypes is cheap, safe and perspective method of complex diagnostics to prognose nosocomial pneumonia and its duration and complications in patients after polytrauma.


Key words

polytrauma, cytokines, nosocomial pneumonia, gene polymorphisms.

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