Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 19, Art. 31 (pp. 418-430)    |    2018       

»

The peculiarities of pre-transfusional status in patients with hereditary disorders of hemostasis

Kargin V.D., Soldatenkov V.E., Mineeva N.V., Papayan L.P., Kapustin S.I., Chechetkin A.V., Burakov V.V., Komissarov K.A., Gavrovskaya S.V., Silina N.N., Matvienko O.Yu., Titov A.G., Kuzakbirdieva O.Kh., Bessmeltsev S.S.

FSBI Russian scientific research institute of hematology and transfusiology of Federal medical biologic agency

Brief summary

Immunohematologic study of pre-transfusional status in patients with hereditary disorders of hemostasis has been carried out. The hypothesis about common patterns of transfusional risks in patients with hypocoagulable hereditary disorder (hemophilia) as well as in patients with hypercoagulable hereditary disorder (thrombophilia) is substantiated. The results of the study, which included 122 patients with severe and moderate hemophilia, are presented. Anti-thrombocytic antibodies were found in 48.1% of patients, anti-granulocytic antibodies ? in 75.83%, allo-erythrocytic antibodies ? in 15.2%. Those circumstances could determine the high risk of transfusional complications. Viral hepatitis is considered as the additional risk factor. The use of the autologous hemocomponents is suggested in such clinical case.


Key words

hemophilia, antibodies, viral hepatitis, thrombophilia, autologous hemocomponents

Reference list

1. Mollison P. L., Engelfriet C.P., Contreras M. Blood transfusion in clinical medicine. Blackwell. - 10th edition. - 1997.


2. Golovkina L.L., Zotikov E.A. Alloimmynizaciya k antigenam sistem NRA i HLA y gematologicheskih bolnih s mnojestvennimi transfyziyami komponentov krovi //Novoe v transfyziologii. - 2003. - N 34 - S.12-22.


3. Zareckaya U.M., Donskov S.I. Immynologicheskaya bezopasnost gemokomponentnoi terapii segodnya i zavtra //Problemi gematologii. - 1998 - N3 - S.7-13.


4. Balyda V.P., Balyda M.V., Goldberg A.P. i dr. // Predtromboticheskoe sostoyanie. Tromboz i ego profilaktika. - M. - Amsterdam. - 1999. - 297 s.


5. Zotikov E.A., Babaeva A.G., Golovkina L.L. Trombociti i antitrombocitarnie antitela. M.: Monolit, - 2003. - S.128.


6. Kapystin S.I. Molekylyarno - geneticheski aspekti patogeneza venoznogo tromboemboltizma: Avtoref. diss. dokt. biol. nayk. 2007 - SPb. - 41 s.


7. Kapystin S. I. Nasledstvennaya trombofiliya kak poligennaya patologiya // Tromboz, gemostaz i reologiya. - 2006. - s 2. - S 24-34.


8. Dytkevich I. G. Osnovi klinicheskoi immynogematologii: Ychebnoe posobie. - SPb.: Izd-vo SPbGMY im I.I. Sechenova, 2014. - S 44-51.


9. Zarivchackii M.F. Transfyziologiya: Klinicheskoe rykovodstvo. - Perm: GBOY VPO PGMA im. ak. E.A. Vagnera, 2014. - 900 s.


10. Kargin V.D. Osobennosti transfyziologicheskogo obespecheniya planovih ortopedicheskih operacii y bolnih gemofiliei. Medicinskaya tehnologiya / V.D. Kargin, L.P. Papayan, V.E. Soldatenkov i dr. - SPb., 2010. - 24 s.


11. Rymyancev A.G. Gemotransfyzionnaya terapiya / A.G. Rymyancev, V.A. Agranenko. - M.:MAKS Press, 2002. - 643 s.


12. Pashkova I.A. Posttransfyzionnie reakcii i oslojneniya. Ychebno-metodicheskoe posobie / I.A. Pashkova, N.V. Mineeva Krasnodar: OOO «Tri-Mil», 2018. - 30 s.


13. Prikaz Minzdrava RF ot 25.11.2002 N 363 Ob ytverjdenii Instrykcii po primeneniu komponentov krovi (Zaregistrirovano v Minuste RF 20.12.2002 N 4062).


14. Prikaz Minzdrava Rossii ot 22.04.2014 N 183n (red. ot 27.07.2018) Ob ytverjdenii perechnya lekarstvennih sredstv dlya medicinskogo primeneniya, podlejashih predmetno-kolichestvennomy ychety.


15. AABB Technical Manual, 16th ed. - Bethesda: AABB - 2008. - 1002 p.


16. Spiess B.D., Spence R.K., Shander A. Perioperative transfusion medicine// Lippincott Williams and Wilkins, 2006. - 697 p.