FSBI Russian scientific research institute of hematology and transfusiology of Federal medical biologic agency
Immunohematologic study of pre-transfusional status in patients with hereditary disorders of hemostasis has been carried out. The hypothesis about common patterns of transfusional risks in patients with hypocoagulable hereditary disorder (hemophilia) as well as in patients with hypercoagulable hereditary disorder (thrombophilia) is substantiated. The results of the study, which included 122 patients with severe and moderate hemophilia, are presented. Anti-thrombocytic antibodies were found in 48.1% of patients, anti-granulocytic antibodies ? in 75.83%, allo-erythrocytic antibodies ? in 15.2%. Those circumstances could determine the high risk of transfusional complications. Viral hepatitis is considered as the additional risk factor. The use of the autologous hemocomponents is suggested in such clinical case.
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