1) The federal state scientific institution Institute of toxicology Federal medico-biological agency Russia, 192019, Saint Petersburg, Bekhterevast., 1.
2) The federal state budget military educational institution of higher education Military medical academy named after S.M. Kirov. Russia, 194044, St. Petersburg, Academician Lebedevst., 6.
3) The federal state budgetary institution B.P. Konstantinov Saint Petersburg nuclear physics institute National Research Center Kurchatov institute. Russia, 188300, Leningrad Region, Gatchina, Orlovaroshcha, 1.
4) The Federal state budgetary institution of higher education First Pavlov St. Petersburg state medical university. Russia, 197022, St. Petersburg, LvaTolstogost., 6-8.
Brief summary
As a result of this study, a group of endogenous and exogenous factors of development of chronic gastritis in individuals working at storage facilities and the destruction of highly toxic organophosphorus compounds has been identified. The endogenous factors are: the age of up to 30 years, the genotype of QR according to polymorphic variant Q191R of the gene of paraoxonase 1, the exogenous are the nature of labor activity, indicating a possible interaction of the organism with organophosphorus compounds. Individuals working out with OPC and carrying the QR genotype QR variant Q191R gene of the paraoxonase 1 should be identified as a group with risk for the formation of gastrointestinal pathology (chronic gastritis) for dynamic monitoring with the purpose of early diagnostic and the provision of preventive and curative measures.
9. Rydakova E.V. O-fosforilirovannie etiltriftorlaktati i geksaftorizopropanoli kak ingibitori serinovih esteraz in vitro i in vivo: dis. kand. him. nayk. Chernogolovka; 2014.
10. Boehm D, Krzystek-Korpacka M, Neubauer K, Matusiewicz M, Berdowska I, Zielinski B et al.Paraoxonase-1 status in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2009;15(1):93-9.
11. Razgildina N.D., Miroshnikova V.V., Fomichev A.V., Malisheva E.V., Panteleeva A.A., Pchelina S.N. Issledovanie aktivnosti paraoksonazi 1 y rabotnikov predpriyatii, dlitelno kontaktiryushih s fosfororganicheskimi soedineniyami. Ekologicheskaya genetika. 2017;15(1):57-63.
12. Fomichev A.V., Miroshnikova V.V., Halimov U.Sh.,Golofeevskii V.U.,Yazenok A.V., Kyzmich V.G. i dr. "Esteraznii statys" y rabotnikov predpriyatii po hraneniu i ytilizacii fosfororganicheskih veshestv, imeushih zabolevaniya jelydochno-kishechnogo trakta. Ychenie zapiski Sankt-Peterbyrgskogo gosydarstvennogo medicinskogo yniversiteta imeni akademika I. P. Pavlova. 2017;24(1):52-7.
13. Rothem L, Hartman C, Dahan A, Lachter J, Eliakim R, Shamir R. Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum Free Radic Biol Med. 2007;43(5):730-9.
14. Kim M.V., Skorukova S.A., Bistrova A.A., Baranova E.I., Pchelina S.N. Polimorfizm Q192R gena paraoksonazi 1 y bolnih saharnim diabetom 2 tipa. Ychenie zapiski Sankt-Peterbyrgskogo gosydarstvennogo medicinskogo yniversiteta imeni akademika I. P. Pavlova. 2014;21(2):69-72.
15. Costa L. G., Richter R. J., Li W.-F., Cole T., Guizzetti M., Furlong C. E. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers. 2003;8(1):1-12.
16. Mackness B, Durrington PN, Mackness MI. Human serum paraoxonase. Gen. Pharmacol. 1998; 31(3):329-36.
17. You T, Lv J, Zhou L. PON1 Q192R and L55M Polymorphisms and Organophosphate Toxicity Risk: A Meta-Analysis. DNA Cell Biol. 2013; 32(5):252-9.