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 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 18, Art. 38 (pp. 561-571)    |    2017       
»

Immunohistochemical study of Ki-67 in various adenomas of the pituitary gland depending on their hormonal profile.
Vorobyova O.M., Ryazanov P.A., Konovalov P.V., Mitrofanova L.B.

Federal State Budgetary Institution Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation, Saint-Petersburg, Russia, 197341



Brief summary

The search for prognostic criteria in oncology is one of the key areas of research. A significant role in this is assigned to the morphological and immunohistochemical criteria. Objective: to evaluate Ki-67 as a prognostic factor for various adenomas of the pituitary gland, depending on their hormonal profile. Materials and methods: analysis of surgical material and medical documentation of 142 patients with pituitary adenomas. A standard histological study was carried out with the staining of hematoxylin and eosin and an immunohistochemical study with antibodies to ki-67 and 6 hormones of adenohypophysis: prolactin, adrenocorticotropic hormone (ACTH), growth hormone (GH), thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Results: macroadenomas predominated over the microadenomas, and in both this groups, mammosomatotropinomas predominated. There were no significant differences in ki-67 between macroadenomas and microadenomas. Recurrent adenomas were larger than non-recurring, but no significant differences in ki-67 levels between this two groups were detected. Adenomas with invasion were larger and had higher values of ki-67 than formations without infestation. The index of proliferative activity of ki-67 of more than 2.6% can be estimated as prognostic criterion of invasive growth only for gonadotropinomas. Conclusion: The role of ki-67 as a prognostic criterion for pituitary adenomas is very limited, both according to our research, and according to the data of foreign authors.


Key words

hormonal types of the pituitary adenoma, prognostic factors, immunohistochemical study, Ki-67.





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