I.M. Sechenov First Moscow State Medical University: women's health research center 1,
university hospital N2 2,
department of clinical pharmacology and propedeutics of internal diseases 3;
I.P. Pavlov Ryzan State Medical University, department of obstetrics and gynecology 4
Objective of this study was to evaluate the effectiveness and safety of using a succinate-based dietary supplement complex (SBDSC) to relieve vasomotor and psychosomatic symptoms in perimenopausal and postmenopausal women. Methods. Randomized, double-blind, placebo-controlled trial was conducted among women 42?60 years of age with vasomotor and psychosomatic menopausal symptoms. The study included medical evaluations, questionnaires using the Greene Climacteric Scale and the Spielberger-Hanin test, evaluation of plasma levels of gonadotropins, estradiol, leptin, and apolipoproteins. Results. The study included 104 women, randomized to two groups. Analysis of the Greene Climacteric Scale results showed a statistically significant (р<0.05) improvement in 13 out of 21 menopausal symptoms in patients who took SBDSC. During the course of the SBDSC treatment and by the end of the study the patients showed significant changes in the levels of estradiol and gonadotropins, decrease in the average body weight and waist circumference. The Spielberger-Hanin test showed that SBDSC supplementation allows for stabilization of patients? psychological status with significant reduction in anxiety, increased resistance to stress, and improved adaptability. Comparative analysis of vital signs, blood and urine tests did not show any negative effects of SBDSC. Conclusion: using SBDSC during menopause and postmenopause can be considered a method to relieve vasomotor and psychosomatic menopausal symptoms for women who have counter indications for HRT or do not wish to undergo HRT.
menopause, vasomotor and psychosomatic menopausal symptoms, mitochondrial dysfunction, treatment of menopausal symptoms, ammonium succinate.
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