The article deals with the result of study systemic immunity indications of 51 patients with autoimmune endometritis, chronic endometritis and the absence of endometritis, according to the immunohistochemical method. With the presence of autoimmune endometritis, immunological response is characterized with a decrease of cytotoxic lymphocytes (CD3+CD8+), the decrease of T-killer cells (CD3+CD16+CD56+), the increase of immunoregulation index (CD3+CD4+/CD3+CD8+), the increase of Ig A and IFN-γ in the blood, which confirms the autoimmune type of inflammation. Differential diagnosis of chronic inflammation in the endometrium is needed by assessing the local immune status by immunohistochemical method and by assessing the overall immune status to apply the pathogenetically substantiated program of immunotherapy.
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