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 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
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«
Vol. 16, Art. 81 (pp. 916-933)    |    2015       
»

New ways to improve the mobilization of hematopoietic stem cells: literature review
1N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia
2Saint-Petersburg State Pediatric Medical University, St. Petersburg, Russia
3North-Western state medical University named I. I. Mechnikov, St.Petersburg, Russia



Brief summary

The study of hematopoietic stem cells mobilization and most recent approaches to usage of new mobilizing agent plerixafor are reveals in the article. The research of plerixafor interacting with various growth factors including pegylated filgrastim is considered to be the most promising direction. This method is believed to help patients with low mobilizing activity where all other means have failed to improve it. The possibility of obtaining a sufficient number of hematopoietic material using plerixafor allows us to perform a course of high-dose chemotherapy with stem cell transplantation in time and therefore achieve high results in patients with a poor prognosis.


Key words

hematopoietic stem cells, hematopoietic stem cells mobilization, high-dose chemotherapy, pleriхafor, pegfilgrastim





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