State budgetary educational institution of higher professional education «Samara state medical University», Ministry of health of Russia
The actual task of pharmacology is currently a search for new drugs with different biological activities, including a diuretic. Studied acute toxicity of humic substances and fulvate magnesium, it was found that both experimental tools belong to class IV toxicity (low hazardous substances) in accordance with GOST 12.1.007-76. Analyzed the effect of humate magnesium and fulvate magnesium on renal excretion of water, ions and creatinine in rats, installed diuretic doses.
magnesium humate, magnesium fulvate, furosemide, diuretic activity, the excretory function of the kidneys, acute toxicity.