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Vol. 16, Art. 57 (pp. 619-638)    |    2015       

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The study of biological properties and therapeutic efficacy of liposomal preparations for intravenous infusion «Lipoferol» in the experiment

Shanskaja A.I., Puchkoya S.M., Khmylova G.A., Nedachina N.A.

Russian Research Institute of Hematology and Transfusiology FMBA of Russia

Brief summary

The results of experimental study of liposomal infusion solution with alpha-tocopherol "Lipoferol." It was found that the drug Lipoferol provides the normalization of acid-base balance of the body, reduces the level of intoxication, the recovery of the structure of cell membranes, inhibits lipid peroxidation. The drug is non-toxic, does not cause anaphylactic and allergic reactions, it does not adversely affect the functional activity of vital organs and hemostasis. The efficiency of the new liposomal drug "Lipoferol" as antioxidant, antihypoxic, hepatoprotective, detoxifying and membrane stabilizing agent in infusion-transfusion therapy of extreme conditions.


Key words

alpha-tocopherol, Lipoferol, antioxidants, antihypoxants, hepatoprotector, intoxication, therapeutic efficiency.

Reference list

1. Lyjnikov, E.A. Endotoksikoz pri ostrih ekzogennih otravleniyah / E.A. Lyjnikov, U.S. Goldfarb, A.M. Marypov. – M.: Izd-vo BINOM, 2008. – 200 s.


2. Medicinskaya toksikologiya: nacionalnoe rykovodstvo / pod red. E.A. Lyjnikova. – M.: GEOTAR-Media, 2012. – 928 s.


3. Shanskaya A.I., Pychkova S.M., Nedachina N.A., Hmilova G.A. Issledovanie frakcionnogo sostava fosfolipidnih komponentov liposomalnogo preparata Lipoferol s primeneniem ysovershenstvovannogo metoda tonkosloinoi hromatografii // Biomedicinskii jyrnal Medline.ru. – 2015. – T. 15. – St. 57. – S. 718-730. [Elektronnii resyrs]. URL: http://www.medline.ru/public/art/tom15/art57.html


4. Lekarstvennie preparati v Rossii: spravochnik /M.: AstraFarmServis. – 2005. – 1536 s.


5. Spravochnik lekarstvennih preparatov Vidal. Opisanie lekarstvennih sredstv. – http://www.vidal.ru.


6. «Sanitarnie pravila po ystroistvy, oborydovaniu i soderjaniu eksperimentalno-biologicheskih klinik (vivariev)», ytverjdennie Glavnim Gosydarstvennim sanitarnim vrachom 06.04.1973 goda №1045-73.


7. Prikaz Minzdrava SSSR ot 12.08.1977 № 755 «Pravila provedeniya rabot s ispolzovaniem eksperimentalnih jivotnih». – M., 1977. – 17 s.


8. Rykovodstvo po eksperimentalnomy (doklinicheskomy) izycheniu novih farmakologicheskih  veshestv / Pod red.  R.Y. Habrieva. – 2-e izd. – M.: Medicina. 2005. – S. 832.


9. Rykovodstvo po eksperimentalnomy (doklinicheskomy) izycheniu novih farmakologicheskih veshestv /pod obsh. redakciei R. Y. Habrieva, I. A. Denisova, V. B. Gerasimova, V. G. Kykesa. — M.: 2005. — 359 s.


10. Kochetigov N.I., Remizova M.I., Makeev A.B., Shanskaya A.I. i dr. Izychenie lechebnoi effektivnosti liposom pri ojogovom shoke v eksperimente // Vestnik slyjbi krovi Rossii.- 1999. – №2. – S. 45-49.


11. Malahova, M.Ya. Metodi biohimicheskoi registracii endogennoi intoksikacii / M.Ya.Malahova // Efferentnaya terapiya. – 1995. – T. 1, № 1. – S. 61–63.


12. Sokolskaya V.A. Vliyanie antioksidantov na enzimaticheskie pokazateli miokarda pri tyajelih ojogah v eksperimente // Ojogovaya bolezn. – Kiev. – 1984. – S. 115-116.


13. Rykovodstvo po obshei i klinicheskoi transfyziologii /pod redakciei U.L. Shevchenko, V.N. Shabalin, M.F.Zarivchackii, E.A.Selivanov. – SPB: OOO «Izdatelstvo Foliant», 2003. – 608 s.


14. Transfyziologiya: Klinicheskoe rykovodstvo /pod redakciei M.F. Zarivchackogo. – Perm: 2014. – 900 s.


15. Kozlov, V.K. Sepsis. Etiologiya, immynopatogenez, koncepciya sovremennoi immynoterapii / V.K.Kozlov. – Kiev: ANNA-T, 2007. – 296 s.