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Vol. 16, Art. 16 (pp. 187-202)    |    2015       

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Development of experimental models of alcoholic hepatitis of varying severity

Petrov A.N., Shevchuk M.K., Georgianova E.K., Sivak K.V., Stosman K.I.

Federal State Institution of Science "Institute of Toxicology, Federal Medical-Biological Agency"

Brief summary

We represent two experimental models of alcoholic hepatitis based on intragastric administration of progressively increasing doses of rectified alcohol in intact animals or animals with a pre-formed liver disease caused by toxic effects of carbon tetrachloride. In the first case within 2.5 months we obtained alcoholic hepatitis of mild to medium severity depending on the duration of administration and dose; in the second case abnormality develops within 8 days. The latter model can be used for express-screening of hepatoprotective preparations.


Key words

Alcoholic hepatitis, experimental models, biomarkers, hepatoprotective preparations, cytolysis, cholestasis.

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