Опубликовать статью

Информационное партнерство

Инфоресурсы

Контакты

«

Vol. 15, Art. 58 (pp. 731-741)    |    2014       

»

The state of hemostasis and the сharacter of allelic polymorphism of genes associated with dysfunction of hemostasis in children with primary and secondary glomerulonephritis

Papayan K. *, Kapustin S. **, Savenkova N.*, Golovina O. **, Tarkovskaya L. **, Papayan L. **, Kachanova T. ***

* The Department of faculty Pediatric, Saint-Petersburg State Pediatric Medical University, e-mail: papayan@inbox.ru;
** Laboratory of blood coagulation, laboratory of biochemistry, Russian Research Institute of Hematology and Transfusiology; Saint-Petersburg
*** Department of automation and control processes, St. Petersburg state Electrotechnical University «LETI»

Brief summary

In 151 patients: 31 with hormone-sensitive nephrotic syndrome (NS); 95 with primary chronic glomerulonephritis (GN) and 25 patients with secondary GN in systemic vasculitis investigated indicators of coagulation hemostasis and the nature of allelic polymorphism of genes associated with dysfunction of hemostasis. As a result of the study, the patients with primary and secondary glomerulonephritis defined some differences in coagulation status and nature of allelic polymorphism of genes associated with dysfunction of hemostasis. Signs of hypercoagulability identified in persons of the 1st and 3rd groups. A large degree of hypercoagulability characterized patients of the 1st group with hormone-sensitive nephrotic syndrome, which is in contrast to the patients of the 3rd group with secondary GN, associated with systemic vasculitis, the activity of antithrombin was significantly reduced. In patients of the 2nd group with chronic GN blood coagulation statistically not significantly different from those of the normal group and were correspondingly lower than in patients with other two groups. A distinctive feature of patients with chronic GN was the increased activity of antithrombin compared with the control group. The greatest intensity of hypercoagulation along with high frequency of occurrence of mutation FV Leiden – 12, 9% (OR=3,2; p=0.07) characterized only patients with NS, which indicates the role of thrombophilic status in the development of the most severe forms of glomerulonephritis.


Key words

children, glomerulonephritis, hemostasis, thrombophilia, the polymorphism of

Reference list

. Movchan, E.A. Disfynkciya endoteliya i trombocitov pri hronicheskoi bolezni pochek: novii vzglyad na staryu problemy naryshenii v sisteme gemostaza y bolnih glomerylonefritom. / E.A. Movchan // Bulleten sibirskoi medicini – 2008. – Prilojenie 2. – S. 88-96.


2. The nephrotic syndrome: pathogenesis and treatment of edema formation and secondary complications. / M.A. Cadnapaphornchai, O. Tkachenko, D. Shchekochikhin, R.W. Schrier // Pediatr Nephrol. – 2014. – Vol. 29, №7. – P. 1159-1167.


3. Sagripanti, A. Hypercoagulability Intraglomerular Coagulation, and Thromboembolism in Nephrotic Syndrome / A.Sagripanti, G.Barsotti // Nefron. – 1995. – Vol. 70. – R. 271-281.


4. Bauman, M. Disordered Hemostasis and Renal Disorders. / M. Bauman, M.P. Massicotte, V. Yiu // “Comprehensive pediatric nephrology” Chapter 26. Edited by Geary D.F., Schaefer F. – 1st ed. Mosby, 2008 – P. 385-394.


5. Detskaya nefrologiya: rykovodstvo dlya vrachei. / pod red. Ignatovoi M.S. 3-e izd., pererab. i dop. M. : OOO «Medicinskoe informacionnoe agenstvo», 2011. – 696 s.


6. Alekseev, N.A. Gematologiya i immynologiya detskogo vozrasta. / N.A. Alekseev SPb : Gippokrat, 2009. – 1044 s.


7. Panutina, Ya.V. Narysheniya gemostaza pri nefroticheskom sindrome glomerylonefrita / Ya.V. Panutina, K.A. Papayan, N.D. Savenkova // Nefrologiya. 2004. – T. 8, № 4. – S. 32-40.


8. Panutina, Ya.V. Narysheniya gemokoagylyacionnogo zvena gemostaza y detei s nefroticheskim sindromom s minimalnimi izmeneniyami : avtoreferat dis. … kand. med. nayk. / Panutina Yana Viktorovna – SPb, 2007.


9. Fynkcionalnoe sostoyanie pochek i pochechnoi gemodinamiki y detei s nasledstvennoi trombofiliei / O.L. Chygynova, M.V. Shymihina, N.L. Kozlovskaya, A.I. Gyrevich. // Nefrologiya i dializ. – 2012. – T. 14, № 4. – S. 224-235.


10. Sistema samozashiti pochki: sovremennii vzglyad na mehanizmi, opredelyaushie techenie i ishod glomerylonefrita / I.N. Bobkova, N.V. Chebotareva, L.V. Kozlovskaya [i dr.] // Nefrologiya i dializ. – 2013. – №15(3). – S. 174-183.


11. Management of Childhood Onset Nephrotic Syndrome / Debbie S.Gipson, Susan F.Massengill, Lynne Yao, Shashi Nagaraj, William E.Smoyer, John D.Mahan, [et al.] // Pediatrics. – 2009. – Vol. 124. – R. 747-757.


12. Kerlin, B.A. Venous thromboembolism in pediatric nephritic syndrome. / B.A. Kerlin, K. Haworth, W.E. Smoyer // Pediatr Nephrol. – 2014. – Vol. 29. – P. 989-997.


13. The nephrotic syndrome: pathogenesis and treatment of edema formation and secondary complications. / M.A. Cadnapaphornchai, O. Tkachenko, D. Shchekochikhin, R.W. Schrier // Pediatr. Nephrol. – 2014. – Vol. 29., № 7. – P.1159-1167.


14. Panutina, Ya.V. Narysheniya v sisteme gemostaza y detei s nefroticheskim sindromom. / Ya.V. Panutina, N.U. Natochina, K.A. Papayan // Klinicheskaya nefrologiya detskogo vozrasta. – SPb, Levsha, 2008. – S. 502-508.


15. Chyprova, A.V. Antikoagylyantnaya terapiya glomerylonefritov: obosnovanie, strategiya, taktika ispolzovaniya. / A.V. Chyprova, S.A. Loskytova // Materiali III Kongressa pediatrov-nefrologov Rossii. – (Sankt-Peterbyrg, dekabr 2003 g.). SPb : Izdanie SPbGPMA, 2003. – S. 49-52.