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Vol. 15, Art. 48 (pp. 605-619)    |    2014       

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Endoscopic and morphological features of pathology of the stomach and duodenum at the persons which were involved in works with organophosphorus compounds.

Golofeevsky V.Y., Fomichev A.V., Khalimov Y.S., Yasenok A.V., Kuzmich V.G., Malysheva E.V.

Military Medical Academy named after SM Kirov

Brief summary

163 people were examined, which were involved in works with Organophosphorus compounds and 40 people the control group. Esophagogastroduodenoscopy, helicobacter pylori express-test, morphological research of biopsy samples of gastric and duodenum bulb mucous were held. The results were processed by original software modules based on Microsoft Access 7.0 pack. In both groups signs of superficial and erosive changes of gastric mucous were detected with different frequencies. People who worked with Organophosphorus compounds were diagnosed erosive gastritis much more often (25%), than people of the control group (5%). The morphological examination in the main group significantly more often showed signs of fibrosis, atrophy of the antral gland and active inflammation in combination with a high frequency of Helicobacter pylori infection. Higher frequency of active bulbitis and peptic ulcer disease was identified in a first group. Morphologically in comparison with the control group microcirculation disorders, edema, high level of lymphoplasmacytic infiltration were also identified significantly more often. Estimating activity of gastric peristalsis, signs of hypermotor dysfunction were diagnosed in 30% cases in the main group, while in a control group in 14.7%. The formation of inflammatory-erosive changes of gastric and duodenum bulb mucous is identified more often in people who work with Organophosphorus compounds. The cause of diagnosed disorders of gastric and duodenum bulb mucous is, probably, complex of objective adverse industrial factors.


Key words

Organophosphorus compounds, Esophagogastroduodenoscopy, morphological research, inflammatory-erosive changes of gastric and duodenum bulb mucous, disfunction, erosive gastritis, microcirculatory disorders.

Reference list

1. Golofeevskii V.U, Vvedenie v klinicheskyu morfologiu jelydka i dvenadcatiperstnoi kishki/ V.U. Golofeevskii.- SPb.: Foliant, 2005. – S.112.


2. Golofeevskii V.U, Innovacionnii podhod k oformleniu, arhivacii i statisticheskoi obrabotke rezyltatov endoskopicheskogo i morfologicheskogo issledovanii / V.U. Golofeevskii, A.V. Fomichev, V.G. Kyzmich, E.V. Malisheva. // Gastroenterologiya. Sankt- Peterbyrga: naychno - prakticheskii jyrnal. - SPb.,2013.- № 2 - S.8.


3. GOST 12.1.005-88. SSBT. Obshie sanitarno-gigienicheskie trebovaniya k vozdyhy rabochei zoni. – Vved. 1989-01-01.- M.: Izd-vo standartov, 1987.- 25 s.


4. Kakorina E.P., Ispolzovanie pokazatelei nacionalnoi bazi dannih «Medstat» v pakete DPS / E.P. Kakorina. - Vrach i informacionnie tehnologii - 2006.- S.53-55.


5. Rapoport S. I. Gastriti (Posobie dlya vrachei) / S.I. Rapoport.- M.: ID «Medpraktika-M», 2010- S.20.


6. Sosukin A.E. «Dannie stacionarnogo obsledovaniya personala obektov hraneniya i ynichtojeniya himicheskogo oryjiya»/ A.E. Sosukin, A.V. Yazenok. // Voenno-medicinskii jyrnal.- 2008.- № 2 - S. 25-27.


7. Yspenskii V.M., Fynkcionalnaya morfologiya slizistoi obolochki jelydka / V.M. Yspenskii. - L.,-1986 - S.291.


8. Firsova L. D. Zabolevaniya jelydka i dvenadcatiperstnoi kishki / L.D. Firsova.— M: Planida, 2011. – S.52.


9. Miranda J., Muscular strength and vibration thresholds during two years after acute poisoning with organophosphate insecticides / J.Miranda, R.Connell, C.Wesseling C. // Occup. and Environ. Med. 2004. – P. 4.