163 people were examined, which were involved in works with Organophosphorus compounds and 40 people the control group. Esophagogastroduodenoscopy, helicobacter pylori express-test, morphological research of biopsy samples of gastric and duodenum bulb mucous were held. The results were processed by original software modules based on Microsoft Access 7.0 pack. In both groups signs of superficial and erosive changes of gastric mucous were detected with different frequencies. People who worked with Organophosphorus compounds were diagnosed erosive gastritis much more often (25%), than people of the control group (5%). The morphological examination in the main group significantly more often showed signs of fibrosis, atrophy of the antral gland and active inflammation in combination with a high frequency of Helicobacter pylori infection. Higher frequency of active bulbitis and peptic ulcer disease was identified in a first group. Morphologically in comparison with the control group microcirculation disorders, edema, high level of lymphoplasmacytic infiltration were also identified significantly more often. Estimating activity of gastric peristalsis, signs of hypermotor dysfunction were diagnosed in 30% cases in the main group, while in a control group in 14.7%. The formation of inflammatory-erosive changes of gastric and duodenum bulb mucous is identified more often in people who work with Organophosphorus compounds. The cause of diagnosed disorders of gastric and duodenum bulb mucous is, probably, complex of objective adverse industrial factors.
Organophosphorus compounds, Esophagogastroduodenoscopy, morphological research, inflammatory-erosive changes of gastric and duodenum bulb mucous, disfunction, erosive gastritis, microcirculatory disorders.
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