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Vol. 15, Art. 21 (pp. 229-237)    |    2014       

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Develop experimental model for evaluating the effectiveness of medications at chronic nonspecific lung diseases

K.S. Kolbasov, V.A. Kashuro, M.V. Melikhova

Federal State Institution of Science
"Institute of Toxicology of the Federal Medical and Biological Agency"

Brief summary

As a result of experiments on white rats using a combined chronic inhalation exposure to dust and prolonged sensitization by subcutaneous injection of serum albumin developed an experimental model that reproduces the main pathogenesis of chronic nonspecific lung diseases. The developed model can be used to study chronic nonspecific lung diseases and assess the effectiveness of treatment and prevention.


Key words

experimental model; chronic nonspecific lung diseases; dusty conditions; treatment; «Salbufen»; rat.

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