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Vol. 15, Art. 14 (pp. 142-154)    |    2014       

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Mechanisms of neurotoxicity of carbon monoxide

P.G. Tolcach, V.A. Basharin, A.N. Grebenuk

Military Medical Academy S.M. Kirov named, St. Petersburg, Russia

Brief summary

In the review are present information about the leading role of carbon monoxide as a gaseous combustion product. The basic pathogenetic neurotoxic action of carbon monoxide are described. The interaction of carbon monoxide with haemoproteins are considered. Its role in the activation of free radical oxidation in the brain are shown. The effect of carbon monoxide on system of soluble guanylate cyclase and cyclic guanosine monophosphate are present. The data about role of carbon monoxide in the mechanism of excitotoxicity are represent.


Key words

carbon monoxide, neurotoxicity, haemoproteins, free radical oxidation, delayed neurological impairment.

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