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Vol. 14, Art. 93 (pp. 1211-1217)    |    2013       

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Attempt of metabolic correction of osteopenia in experiment and clinic during the completion of ovulatory cycle

Uchitel1 ML, Bolotanova1, 2 MK, Nech aev2А.Н, Vasileva1A.A., Grishina1 EN, Pogorelov1 A.G., Pogorelova1 V.N., Bogdanova1 L.A., Maevsky1 E . I.

Brief summary

It was shown the possibility of reducing the involutional osteopenia at the completion of ovulatory cycle by using succinate-glutamate composition (SGK) without the application of hormone replacement therapy. In female mice, which were in early postreproductive period, 4 -week introduction to the diet of SGK in the daily dose 25 mg / kg significantly contributed to the increment of wet and dry weight of the femur and caused pronounced tendency to increase its ash weight. Though X-Ray densitometry indicators did not reveal clear changes of bone density. In 10 women in postmenopausal age of 2 weeks SGK treatment contributed to significant reduction of osteopenia in Ward zone.


Key words

metabolic therapy, osteopenia, bone weight indexes, X-ray densitometry

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