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Vol. 14, Art. 89 (pp. 1131-1145)    |    2013       

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HLA-DPB1 disparity as a risk factor of acute graft-versus-host disease after 10/10 hla matched-unrelated donor hsct

Kuzmich E.V., Alynskiy A.A., Alekseikova I.A., Ivanova N.E., Barkhatov I.M., Fediukova I.G., Bondarenko S.N.

First Pavlov State Medical University of St. Petersburg, Raisa Gorbacheva Memorial Institute for Pediatric Oncology, Hematology and Transplantation

Brief summary

Hematopoietic stem cell transplantation (HSCT) with 10 of 10 allele matched unrelated donors is still associated with a significant risk of acute graft-versus-host disease (aGVHD). In order to estimate the HLA-DPB1 disparity as a risk factor of aGVHD for our cohort patients, we used algorithm for the classification of HLA-DPB1 mismatches based on T-Cell Epitope (TCE) groups (www.ebi.ac.uk/ipd/imgt/hla/dpb.html). TCE-non-permissive HLA-DPB1 mismatches in the HvG direction are potentially negative prognostic factor of the risk of severe aGVHD for the adult patients of our cohort undergoing unrelated allogeneic HSCT with using non-myeloablative conditional regimes.


Key words

unrelated allogeneic hematopoietic stem cell transplantation, graft-versus-host disease, HLA-DPB1 disparity of the donor and recipient.

Reference list

1. Afanasev B.V., Zybarovskaya L.S. Transplantaciya gemopoeticheskih stvolovih kletok krovi // Detskaya onkologiya. Rykovodstvo. – 2002. - S-Peterbyrg. – str. 90-108.


2. Zybarovskaya L.S., Fregatova L.M., Afanasev B.V. Transplantaciya gemopoeticheskih stvolovih kletok pri gemoblastozah // Klinicheskaya onkogematologiya pod red. prof. M.A. Volkovoi. 2 izdanie. – 2007. – Moskva.


3. Petersdorf E. The major histocompatibility complex: a model for understanding graft-versus-host disease. // Blood. -  2013. – Vol. 122. – pp. 1863-1872.


4. Begovich A.B., McClure G.R., Suraj V.C. et al. Polymorphism, recombination and linkage disequilibrium within the HLA class II region // J. Immunol. – 1992. – Vol. 148. – pp. 249-258.


5. Petersdorf E.W., Gooley T., Malkki M. et al. The biological significance of HLA-DP gene variation in hematopoietic cell transplantation // Br. J. Hematol. – 2001. – Vol. 112. – pp. 988-994.


6. Zino E., Frumento G., Marktel S. et al. A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation // Blood. - 2004. - Vol.103. - pp. 1417-1424.


7. Zino E., Vago L., Di Terlizzi S. et al. Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation // Biol. Blood Marrow Transplant. - 2007. - Vol.13, N.9. - pp. 1031-1040.


8. Crocchiolo R., Zino E. et al. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation // Blood.- 2009.- Vol.114.- pp.1437-1444.


9. Fleischhauer K., Shaw B.E., Gooley T., Malkki et al. Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study // Lancet Oncology. – 2012. – Vol. 13. – pp. 366-374.


10. Thus K.A., Ruizendaal T.A., De Hoop T. et al. Confirmation of and explanation for the effect of HLA-DPB1 non-permissive mismatches after 10/10 HLA matched-unrelated donor stem-cell transplantation: a single center study // Tissue Antigenes. – 2013. – Vol.81, N.5. – pp. 289-290.


11. Fleischhauer, K., Locatelli, F., Zecca, M. et al. Graft rejection after unrelated donor hematopoietic stem cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction // Blood. - 2006. - Vol.107. - pp. 2984–2992.


12. Shaw B.E., Fleischhauer K., Zino E. et al. Significant differences in outcome following unrelated donor HCT can be better predicted using an algorithm incorporating both allele and epitope level matching for HLA-DPB1. Abstract // Bone Marrow Transplantation. – 2009. – Vol. 43. – S78.


13. Glucksberg H., Storb R., Fefer A. et al. Clinical manifestations of graft-vs-host disease in human recipients of marrow from HLA-matched sibling donors // Transplantation.-1974. - Vol.18. - pp. 295-304.


14. Standards for Histocompatibility and Immunogenetics Testing - version 6.0, 2012, EFI. (http://efiweb.eu/)