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Vol. 14, Art. 87 (pp. 1100-1108)    |    2013       

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Dynemics of endogenous intoxication in colorectal cancer patients, complicated by peritonitis

Bezmozgin B.G., Zacharenko A.A., Surov D.A., Babkov O.V.

Djanelidze Research Institute of Emergency Medicine, Saint Petersburg, Russia

Brief summary

Surgical treatment of septic complications of colorectal cancer (CRC) is one of the most urgent problems of modern emergency surgery that is primarily due to high postoperative mortality. Key syndrome, largely determines the dynamics of the disease in these patients is endogenous intoxication syndrome. It represents syndrome characterized accumulation in biological fluids endogenous toxic substances - normal or excess products perverted metabolism or cellular response mediators. The presence and severity of endogenous intoxication causes the usefulness of complementary therapies, the use of which allows you to quickly arrest the manifestations of the syndrome. In this study, we used the method VAC - therapy and demonstrated that the use of this technique in the complex treatment of diffuse peritonitis in patients with CRC promotes more rapid relief of phenomena endotoxemia.


Key words

endogenous intoxication, medium-weight molecules, leukocyte index of intoxication, VAC-therapy, colorectal cancer, peritonitis.

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