Медико-биологический
информационный портал
для специалистов
 
БИОМЕДИЦИНСКИЙ ЖУРНАЛ Medline.ru

СОДЕРЖАНИЕ ЖУРНАЛА:
Физико-химическая биология

Клиническая медицина

Профилактическая медицина

Медико-биологические науки


АРХИВ:

Фундаментальные исследования

Организация здравохраниения

История медицины и биологии



Последние публикации

Поиск публикаций

Articles

Архив :  2000 г.  2001 г.  2002 г. 
               2003 г.  2004 г.  2005 г. 
               2006 г.  2007 г.  2008 г. 
               2009 г.  2010 г.  2011 г. 
               2012 г.  2013 г.  2014 г. 
               2015 г.  2016 г.  2017 г. 
               2018 г. 

Редакционная информация:
        Опубликовать статью
        Наша статистика


 РЕДАКЦИЯ:
Главный редактор

Заместители главного редактора

Члены редколлегии
Специализированные редколлегии


 УЧРЕДИТЕЛИ:
Федеральное государственное бюджетное учреждение науки
"Институт токсикологии Федерального медико-биологического агентства"
(ФГБУН ИТ ФМБА России)

Институт теоретической и экспериментальной биофизики Российской академии наук.

ООО "ИЦ КОМКОН".




Адрес редакции и реквизиты

199406, Санкт-Петербург, ул.Гаванская, д. 49, корп.2

ISSN 1999-6314

Российская поисковая система
Искать: 


«
Vol. 14, Art. 71 (pp. 900-916)    |    2013       
»

Present status of lung cancer screening
Kostitsin K.A.

«N.N. Petrov Research Institute of Oncology», Ministry of Healthcare of the Russia and
St. Petersburg Clinical Research Centre of special types of medical care (Oncology)



Brief summary

This paper summarizes the published data on the effectiveness of lung cancer screening programs and provides preliminary data on thefirst phase of the Russian trial with 324 participants. Paper outlines the necessity of randomized controlled trials, with the primary goal to estimate the mortality from the disease, to make evidence-based conclusions. It is shown that so far only one study (NLST) has achieved a relative reduction in mortality from lung cancer by 20.0% (overall reduction - 6.7%). On the basis of own data it is demonstrated that the implementation of screening should be done with thorough quality control - only 64.7% of CT scans fully satisfy the objectives and only 75.9% of the patients met the inclusion criteria. However, the promising results were shown with the enrollment of participants, and the screening efficiency of the first stage was confirmed by detection of lung lesions in 37.9% of the participants, of whom 19,8% (n=64) had lesions 10 mm or larger. A follow-up algorithm is proposed to further optimize lung cancer diagnostics.


Key words

lung cancer, screening, low-dose computed tomography, quality assurance, lung nodules.





(The article in PDF format. For preview need Adobe Acrobat Reader)



Open article in new window

Reference list

1. Barchyk A.A., Arsenev A.I., Levchenko E.V. Skrining raka lyogkogo // Voprosi onkologii – 2009. № 1. – S. 7-14.


2. Barchyk A.A., Arsenev A.I., Levchenko E.V. i soavt. Avtomatizirovannaya kolichestvennaya citometriya v diagnostike raka lyogkogo // Voprosi onkologii – 2011. t. 57, № 1. – S. 36-42.


3. Barchyk A.A., Arsenev A.I., Levchenko E.V. i soavt. Aytoflyorescentnaya bronhoskopiya i spektrometriya v diagnostike centralnogo raka lyogkogo // Voprosi onkologii – 2011. t. 57, № 4. – S. 448-454.


4. Merabishvili V.M., Sherbyk U.A. Onkologicheskaya slyjba v Sankt-Peterbyrge i raionah goroda v 2008 gody (zabolevaemost, smertnost, vijivaemost). Ejegodnik Popylyacionnogo rakovogo registra // SPb. - 2009. – 240 s. ISBN 978-5-91258-113-7.


5. Rossiiskii statisticheskii ejegodnik. 2009. // Statisticheskii sbornik M., Rosstat, 2009, 795 s.


6. Chissov V.I., Starinskii V.V., Petrova G.V. Zlokachestvennie novoobrazovaniya v Rossii v 2008 gody (zabolevaemost i smertnost) // M.: FGY «MNIOI im. P.A. Gercena Rosmedtehnologii», 2010.− 256 s.: il. ISBN 5-85502-024-H


7. Abdel-Salam M., Mayall B. H., Chew, K. et al. Prediction of malignant transformation in oral epithelial lesions by image cytometry // Cancer. 1988. - 62. – R. 1981–1987.


8. Bajtarevic A., Ager C., Pienz M. et al. Noninvasive detection of lung cancer by analysis of exhaled breath // BMC Cancer. – 2009. - 29; 9. - R. 348-351.


9. Brenner D.J. Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer // Radiology. 2004. - 231(2). – P. 440-445.


10. Carpagnano G.E., Foschino-Barbaro M.P., Resta O. Endothelin-1 is increased in the breath condensate of patients with non-small-cell lung cancer // Oncology. – 2004. - 66(3). – R. 180-184.


11. Consensus statements on prevention and early diagnosis of lung cancer. Varese, Italy, December, 1998 // Oncology (Williston Park). – 1999. - 13(3). – R. 298.


12. Diederich S., Wormanns D., Semik M. et al. Screening for early lung cancer with low-dose spiral CT: prevalence in 817 asymptomatic smokers // Radiology.–2002.–222.–R. 773-781.


13. Fontana R.S., Sanderson D.R., Woolner L.B. et al. Screening for lung cancer. A critique of the Mayo Lung Project // Cancer. – 1991. – 67. – R. 1155-1164.


14. Global health risks: mortality and burden of disease attributable to selected major risks // Geneva, World Health Organiza­tion, 2009. - ISBN 978 92 4 156387 1.


15. Hayata Y., Funatsu H., Kato H. et al. Results of lung cancer screening programs in Japan. Recent Results // Cancer Res. 1982. – 82. – R. 163-173.


16. Henschke C.I., Yankelevitz D.F., Libby D.M. et al. Survival of patients with stage I lung cancer detected on CT screening // N. Engl. J. Med. – 2006. - 355(17). – R. 1763-1771.


17. Hill G., Millar W., Connelly J. "The great debate" 1: Smoking, lung cancer, and cancer epidemiology // Can Bull Med Hist. 2003. – 20(2). – R. 367-386.


18. Hirsch F.R., Prindiville S.A., Miller Y.E. et al. Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study // J. Natl. Cancer Inst. – 2001. - 93(18). – R. 1385-1391.


19. Holmberg L., Sandin F., Bray F. et al. National comparisons of lung cancer survival in England, Norway and Sweden 2001-2004: differences occur early in follow-up // Thorax. - 2010. - 65(5). – P. 436-441.


20. Horn L., Johnson D.H. Evarts A. Graham and the first pneumonectomy for lung cancer // J. Clin. Oncol. – 2008. - 26(19). – P. 3268–3275.


21. Kennedy T.C., Hirsch F.R., Miller Y. et al. A randomized study of fluorescence bronchoscopy versus white light bronchoscopy for early detection of lung cancer in high risk patients // Lung Cancer. – 2000. – 29. – R. 244-247.


22. Jheon S., Hyun D.S., Lee S.C. et al. Lung cancer detection by a RT-nested PCR using MAGE A1--6 common primers // Lung Cancer. – 2004. - 43(1). – R. 29-37.


23. Mathers C., Boerma T., Ma Fat D. The global burden of disease: 2004 update // Geneva, World Health Organiza­tion, 2008. - ISBN 978 92 4 156371 0.


24. Meert A.P., Feoli F., Martin B. et al. Angiogenesis in preinvasive, early invasive bronchial lesions and micropapillomatosis and correlation with EGFR expression // Histopathology. - 2007. - 50(3). – R. 311-317.


25. Nash F.A., Morgan J.M., Tomkins J.G. South London Lung Cancer Study // Br. Med. J. – 1968. - 22; 2(5607). – R. 715-721.


26. Neumann T., Miao Q., Yu J. et al. Simultaneous 3D imaging of morphology and nanoparticle distribution in single cells with the Cell-CT technology // Conf. Proc. IEEE Eng. Med. Biol. Soc. – 2008. – R. 379-381.


27. Palcic B., Garner D.M., Beveridge J. et al. Increase of sensitivity of sputum cytology using high-resolution image cytometry: field study results // Cytometry. – 2002. - 50(3). – R. 168-176.


28. Pastorino U., Bellomi M., Landoni C. et al. Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results // Lancet. – 2003. – 362. – P. 593–597.


29. Sobue T., Moriyama N., Kaneko M. et al. Screening for lung cancer with low-dose helical computed tomography: anti-lung cancer association project // J. Clin. Oncol. – 2002. – 20. – R. 911-920.


30. Swensen S.J., Jett J.R., Hartman T.E. et al. Lung cancer screening with CT: Mayo Clinic experience // Radiology. – 2003. – 226. – R. 756-61.


31. The National Lung Screening Trial Research Team. Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening // N. Engl. J. Med. – 2011. – Vol. 365, No. 5. – P. 395-409.


32. Van der Aalst C.M., van den Bergh K.A., Willemsen M.C. et al. Lung cancer screening and smoking abstinence: 2 year follow-up data from the Dutch-Belgian randomised controlled lung cancer screening trial // Thorax. – 2010. - 65(7). – P. 600-605.


33. Waugh N., Black C., Walker S, et al. The effectiveness and cost-effectiveness of computed tomography screening for coronary artery disease: systematic review //Health Technol. Assess. – 2006. - 10(39). – P. 1-41


34. Weiss W., Seidman H., Boucot K.R. The Philadelphia Pulmonary Neoplasm Research Project. Symptoms in occult lung cancer // Chest. – 1978. - 73(1). – R. 57-61.


35. Zech V.F., Dlaska M., Tzankov A. Prognostic and diagnostic relevance of hnRNP A2/B1, hnRNP B1 and S100 A2 in non-small cell lung cancer // Cancer Detect Prev. – 2006. - 30(5). – R. 395-402.



Свидетельство о регистрации сетевого электронного научного издания N 077 от 29.11.2006
Журнал основан 16 ноября 2000г.
Выдано Министерством РФ по делам печати, телерадиовещания и средств массовых коммуникаций
(c) Перепечатка материалов сайта Medline.Ru возможна только с письменного разрешения редакции

Размещение рекламы

Rambler's Top100