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Федеральное государственное бюджетное учреждение науки
Институт теоретической и экспериментальной биофизики
Российской академии наук


ООО "ИЦ КОМКОН"

Адрес редакции и реквизиты

192012, Санкт-Петербург, ул.Бабушкина, д.82 к.2, литера А, кв.378

ISSN 1999-6314


Клиническая медицина » Терапия • Гематология

Том: 14
Статья: « 66 »
Страницы:. 819-844
Опубликована в журнале: 5 сентября 2013 г.

English version

Роль генетического полиморфизма компонентов плазменного звена гемостаза в патогенезе венозного тромбоэмболизма (обзор литературы)

Демьяненко А.В.1, Капустин С.И.2, Сорока В.В.1, Чечулов П.В.1

1Научно-исследовательский институт скорой помощи им. И.И. Джанелидзе, Санкт-Петербург, Россия
2Российский научно-исследовательский институт гематологии и трансфузиологии, Санкт-Петербург, Россия


Резюме
Тромбоз глубоких вен (ТГВ) и тромбоэмболия легочной артерии (ТЭЛА) остаются серьезной проблемой здравоохранения с ежегодной частотой 1 на 1000 случаев. Венозный тромбоэмболизм (ВТЭ) - это типичное многофакторное заболевание, в основе которого лежит наследственная предрасположенность, или тромбофилия. На сегодняшний день к наследственным тромбофилиям относят дефицит естественных антикоагулянтов (ЕА) – антитромбина III, протеинов C и S, а также мутации в генах факторов V Leiden и протромбин G20210A. Однако анализ симптоматических семей и пациентов с идиопатическим ВТЭ не выявляет данные нарушения более чем в 50% случаях, что свидетельствует о причастности других наследственных факторов к патогенезу заболевания. Цель настоящего обзора – синтезировать и представить накопленные в литературе данные о роли генетического полиморфизма компонентов плазменного звена гемостаза в патогенезе ВТЭ. В качестве материалов были использованы более 50 оригинальных и обзорных научных статей, мета-анализов, посвященных данной проблеме, отечественных и зарубежных авторов, цитируемых в базах данных Medline, PubMed.


Ключевые слова
венозный тромбоз, фактор риска, наследственная тромбофилия



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