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Vol. 13, Art. 86 (pp. 1024-1031)    |    2012       

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The influence of anti-inflammatory drugs or l-carnitine on nitrogen metabolism in acute cyclophosphamide poisoning in rats

Military Medical Academy S.M. Kirov named, 194044, St. Petersburg
*Federal State Science Institution "The Institute of toxicology" FMBA Russian Federation

Brief summary

In cyclophosphamide (CY) myeloablative regimens rat model, the syndrome manifested by depression, ataxia and equilibrium disorders, increased blood ammonia, glutamine and urea levels, was observed. Neurological disorders, portal blood ammonia and blood urea content alterations were mitigated, the mean survival time were increased by the preventive administration of dexamethasone, prednisolone, voltaren or L-carnitine. The role of damaged urinary bladder urothelium and the increased urea recycling in the pathways of CY-induced neurological syndrome has been discussed.


Key words

L-carnitine, cyclophosphamide, ammonia, urea, glutamine

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