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Vol. 13, Art. 85 (pp. 1017-1023)    |    2012       

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Influence of interleukin-1β on radiodefence efficiency of granulocyte- colony-stimulating factor in experiment

Salukhov V.V., Legeza V.I., Pershko V.A.

Military Medical Academy named after SM Kirov Defense Ministry

Brief summary

Relative research is conducted in experiment on rats противолучевой efficacy of course treatment filgrastim and applications interlejkina-1β (in the conditions of preventive and medical introduction) at a marrowy syndrome of sharp radiating lesions. It is positioned that therapy G-CSF at preventive application interleukin-1β is more effective, than isolated and joint application of these drugs, promotes essential augmentation of survival rate, restoration acceleration myeloid a sprout of a marrow and cages of peripheric blood - leucocytes, neutrophils, lymphocytes.


Key words

granulocyte- colony-stimulating factor, interleukin-1β, cytokine, acute radiation syndrome, therapy of radiation injuries

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