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Vol. 13, Art. 47 (pp. 583-596)    |    2012       

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The question of nmda-antagonistic compounds using in shemes of organophosphate-induced seizures therapy

Subbotina S.N., Judin M.A., Kuzmin A.A., Ivanov I.M.

Scientific Research Institute of Military Medicine, S.M.Kirov’s Military Medical Academy

Brief summary

There was shown the possible use of NMDA- antagonistic compounds in shemes of organophosphate-induced seizures therapy in animal experiments. Anticonvulsant activity of source NMDA-blockers is determined by the degree of affinity to the receptor and by the period of administration after exposure (30 min.) There was shown the reduction of medium effective anticonvulsant dose of NMDA- antagonistic compounds provided the use of atropine and HI-6 – compounds of pathogenetic therapy for organophosphate poisoning. The maximum decrease in the effective anticonvulsant dose when used in combination therapy schemes for organophosphate poisoning model is established for CNS-1102.


Key words

organophosphate-induced seizures, anticonvulsant effectivity, NMDA-antagonistic compounds, anticholinergic drugs with antiglutamatergic properties, reactivators of cholinesterase

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