Parenchyma and stroma bone marrow structural features in patients with multiple myeloma
1 Rugal V., 1 Bessmeltsev S., 1 Semenova N., 1 Zenina M., 2 Odinak O.
1 Russian Research Institute of Hematology and Transfusiology,
2 Militari Medical Academy named ofter S.M. Kirov
Brief summary
Studied parenchymal and stromal tissue of the bone marrow in the trephine biopsies 95 patients with multiple myeloma. Identified 5 types of tumor infiltration: nodular, interstitial, interstitial-endosteal, interstitial-nodular, diffuse. Showed changes of stromal microenvironment in all types of bone marrow. Increase in the density of microvessels subendostal zones, change of state of endostal stromal cells and collagen structure of bone showed lesions of niche of hematopoetic stem cells. The defect of niche may be a pathogenetic factor in neoplastic transformation of precursor B-lymphopoesis and function of niche may be directed to the maintenance of leukemic clone.
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