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199406, —анкт-ѕетербург, ул.√аванска€, д. 49, корп.2

ISSN 1999-6314

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«
Vol. 13, Art. 4 (pp. 38-57)    |    2012       
»

The modern conception of the proper role of telomeres and telomerase in pathogenesis of hematologic and oncology diseases
The Federal State Entity УRussian Institute for Hematology and TransfusiologyФ of the Federal Medical-Biological Agency (FMBA) of the Russian Federation (191024, St-Petersburg, 2 Sovietskaya Str. 16, phone: 812 7175938, bloodscience@mail.ru)



Brief summary

The modern methods of biomedical research let us get to know a cutting - edge information in the pathology of diseases. Measurement of telomerase activity and telomere length are new highly informative diagnostic tests. There is set of the diseases such as dyskeratosis congenital, aplastic anemia, myelodisplastic syndrome, acute myeloid leukemia, chronic myeloid leukemia, chronic lymphoid leukemia, multiple myeloma and some other disorders which characterized of genetic instability and telomere alterations. The telomere length changes are representative of processes cell development and degradation. The research of telomere genetic defects and telomere renewal mechanisms are very important for prognosis of disease and treatment choice. The telomere length measurement in peripheral blood leucocytes could be used as a screening method for disease monitoring and prognosis as well as control of treatment efficacy. The telomere length shortening is a strong sign of oncology disease development. The review considers molecular mechanisms of telomere renewal and telomerase activity which could result in hematology disease.


Key words

stem cell, telomere length, telomerase, dyskeratosis congenital, pulmonary fibrosis, aplastic anemia, multiple myeloma, chronic lymphoid leukemia, chronic myeloid leukemia.





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